共 128 条
Tracking the ends: a dynamic protein network controls the fate of microtubule tips
被引:764
作者:

Akhmanova, Anna
论文数: 0 引用数: 0
h-index: 0
机构:
Erasmus MC, Dept Cell Biol, NL-3000 CA Rotterdam, Netherlands Erasmus MC, Dept Cell Biol, NL-3000 CA Rotterdam, Netherlands

Steinmetz, Michel O.
论文数: 0 引用数: 0
h-index: 0
机构:
Paul Scherrer Inst, CH-5232 Villigen, Switzerland Erasmus MC, Dept Cell Biol, NL-3000 CA Rotterdam, Netherlands
机构:
[1] Erasmus MC, Dept Cell Biol, NL-3000 CA Rotterdam, Netherlands
[2] Paul Scherrer Inst, CH-5232 Villigen, Switzerland
关键词:
D O I:
10.1038/nrm2369
中图分类号:
Q2 [细胞生物学];
学科分类号:
071009 ;
090102 ;
摘要:
Microtubule plus-end tracking proteins (+ TIPs) are a diverse group of evolutionarily conserved cellular factors that accumulate at the ends of growing microtubules. They form dynamic networks through the interaction of a limited set of protein modules, repeat sequences and linear motifs that bind to each other with moderate affinities. + TIPs regulate different aspects of cell architecture by controlling microtubule dynamics, microtubule interactions with cellular structures and signalling factors, and the forces that are exerted on microtubule networks.
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页码:309 / 322
页数:14
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