Tracking the ends: a dynamic protein network controls the fate of microtubule tips

被引:764
作者
Akhmanova, Anna [1 ]
Steinmetz, Michel O. [2 ]
机构
[1] Erasmus MC, Dept Cell Biol, NL-3000 CA Rotterdam, Netherlands
[2] Paul Scherrer Inst, CH-5232 Villigen, Switzerland
关键词
D O I
10.1038/nrm2369
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Microtubule plus-end tracking proteins (+ TIPs) are a diverse group of evolutionarily conserved cellular factors that accumulate at the ends of growing microtubules. They form dynamic networks through the interaction of a limited set of protein modules, repeat sequences and linear motifs that bind to each other with moderate affinities. + TIPs regulate different aspects of cell architecture by controlling microtubule dynamics, microtubule interactions with cellular structures and signalling factors, and the forces that are exerted on microtubule networks.
引用
收藏
页码:309 / 322
页数:14
相关论文
共 128 条
[11]   Targeted movement of cell end factors in fission yeast [J].
Browning, H ;
Hackney, DD ;
Nurse, P .
NATURE CELL BIOLOGY, 2003, 5 (09) :812-818
[12]   Characterization of functional domains of human EB1 family proteins [J].
Bu, W ;
Su, LK .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (50) :49721-49731
[13]   STABILIZATION AND POSTTRANSLATIONAL MODIFICATION OF MICROTUBULES DURING CELLULAR MORPHOGENESIS [J].
BULINSKI, JC ;
GUNDERSEN, GG .
BIOESSAYS, 1991, 13 (06) :285-293
[14]   The microtubule plus end-tracking proteins mal3p and tip1p cooperate for cell-end targeting of interphase microtubules [J].
Busch, KE ;
Brunner, D .
CURRENT BIOLOGY, 2004, 14 (07) :548-559
[15]   Tea2p kinesin is involved in spatial microtubule organization by transporting Tip1p on microtubules [J].
Busch, KE ;
Hayles, J ;
Nurse, P ;
Brunner, D .
DEVELOPMENTAL CELL, 2004, 6 (06) :831-843
[16]   Cell cycle control of kinesin-mediated transport of Bik1 (CLIP-170) regulates microtubule stability and dynein activation [J].
Carvalho, P ;
Gupta, ML ;
Hoyt, MA ;
Pellman, D .
DEVELOPMENTAL CELL, 2004, 6 (06) :815-829
[17]   Surfing on microtubule ends [J].
Carvalho, P ;
Tirnauer, JS ;
Pellman, D .
TRENDS IN CELL BIOLOGY, 2003, 13 (05) :229-237
[18]   The FKBP12-rapamycin-associated protein (FRAP) is a CLIP-170 kinase [J].
Choi, JH ;
Bertram, PG ;
Drenan, R ;
Carvalho, J ;
Zhou, HH ;
Zheng, XFS .
EMBO REPORTS, 2002, 3 (10) :988-994
[19]   LIS1, CLIP-170's key to the dynein/dynactin pathway [J].
Coquelle, FM ;
Caspi, M ;
Cordelières, FP ;
Dompierre, JP ;
Dujardin, DL ;
Koifman, C ;
Martin, P ;
Hoogenraad, CC ;
Akhmanova, A ;
Galjart, N ;
De Mey, JR ;
Reiner, O .
MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (09) :3089-3102
[20]   A microtubule-binding domain in dynactin increases dynein processivity by skating along microtubules [J].
Culver-Hanlon, TL ;
Lex, SA ;
Stephens, AD ;
Quintyne, NJ ;
King, SJ .
NATURE CELL BIOLOGY, 2006, 8 (03) :264-270