Apolipoprotein E epsilon 2 does not increase risk of early-onset sporadic Alzheimer's disease

被引：18

作者：

Scott, WK

Saunders, AM

Gaskell, PC

Locke, PA

Growdon, JH

Farrer, LA

Auerbach, SA

Roses, AD

Haines, JL

PericakVance, MA

机构：

[1] DUKE UNIV,MED CTR,DEPT MED,MED GENET SECT,DURHAM,NC 27710

[2] DUKE UNIV,MED CTR,DEPT MED,DIV NEUROL,DURHAM,NC 27710

[3] MASSACHUSETTS GEN HOSP,MOL NEUROGENET UNIT,CHARLESTOWN,MA

[4] MASSACHUSETTS GEN HOSP,DEPT NEUROL,CHARLESTOWN,MA

[5] BOSTON UNIV,SCH MED,DEPT NEUROL,BOSTON,MA 02118

来源：

ANNALS OF NEUROLOGY | 1997年 / 42卷 / 03期

关键词：

D O I：

10.1002/ana.410420317

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We examined the association of apolipoprotein E (ApoE) genotype and the risk of early-onset Alzheimer's disease (AD) in 209 white early-onset sporadic cases (43% male) and 303 white controls (48% male) of similar age distribution. The risk of AD was significantly increased, relative to the 3/3 genotype, in people with the 4/4, 3/4, and 2/4 genotypes, controlling for age at time of examination and sex. The 2/3 genotype reduced slightly the risk of AD, although the effect was not statistically significant. We conclude, contrary to some previous reports, that the ApoE epsilon 2 allele does not increase the risk of early-onset sporadic AD.

引用

页码：376 / 378

页数：3

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