α2-macroglobulin gene polymorphisms show racial diversity and are not associated with Alzheimer's disease

被引：19

作者：

Higuchi, S

Matsushita, S

Nakane, J

Arai, H

Matsui, T

Urakami, K

Yuzuriha, T

Takeda, A

机构：

[1] Kurihama Natl Hosp, Natl Inst Alcoholism, Div Clin Res, Yokosuka, Kanagawa 2390841, Japan

[2] Tohoku Univ, Sch Med, Dept Geriatr Med, Sendai, Miyagi 980, Japan

[3] Tohoku Univ, Sch Med, Dept Neurol, Sendai, Miyagi 980, Japan

[4] Tottori Univ, Sch Med, Dept Neurol, Tottori 680, Japan

[5] Hizen Natl Hosp, Dept Psychiat, Saga, Japan

来源：

NEUROREPORT | 2000年 / 11卷 / 06期

关键词：

Alzheimer's disease; apolipoprotein E; association study; Caucasian; Japanese; alpha(2)-macroglobulin; racial diversity;

D O I：

10.1097/00001756-200004270-00005

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Two generic markers of the plasma protein alpha(2)-macroglobulin, a 5 bp deletion/insertion at the 5' splice site of exon 18 (A2M1) and the GTC/ATC (Val1000Ile) in exon 24 (A2M2), may have roles in the development of Alzheimer's disease (AD). Genotyping and linkage analysis of these markers in 426 Japanese sporadic AD patients, 85 autopsy-confirmed Caucasian AD cases, and, as controls, 382 Japanese and 65 Caucasians who were cognitively normal and 140 Japanese Parkinson's disease patients showed racial diversity in the frequencies and relationship of the two markers. Comparison of genotype and allele frequencies, stratification of the samples by the presence of the apolipoprotein E epsilon 4 allele, and logistic regression analysis revealed no association of these markers with AD in either racial group. NeuroReport 11:1167-1171 (C) 2000 Lippincott Williams & Wilkins.

引用

页码：1167 / 1171

页数：5

共 25 条

[1] Alpha-2 macroglobulin is genetically associated with Alzheimer disease [J].