Products from mast cells influence T lymphocyte proliferation and cytokine production - Relevant to allergic asthma?

In IgE allergic diseases both mast cells and T lymphocytes play an important role. Whereas mast cells have been implicated in immediate allergic responses, T lymphocytes mediate subsequent late phase responses and chronic inflammation. Here we review possible links between the early mast cell activation and the later T lymphocyte stimulation. Products from mast cells were found to exert effects on T lymphocytes. Human Mast Cell line-1 (HMC-1) mast cells modulated proliferation and cytokine production of a human CD8(+) T-cell clone in vitro. Activated mast cells seemed to drive this CD8(+) T-cell clone towards a more pronounced T (helper) 1 type of response, simultaneously decreasing T-cell numbers. It is hypothesized that this might be a negative feed back mechanism operating in allergic subjects, by which the Th2-driven IgE production and eosinophilia are counteracted. (C) 1997 Elsevier Science B.V.