2-mercaptopyridine-1-oxide-based peptide coupling reagents

被引：23

作者：

Albericio, F

Bailén, MA

Chinchilla, R

Dodsworth, DJ

Nájera, C

机构：

[1] Univ Alicante, Fac Ciencias, Dept Quim Organ, E-03080 Alicante, Spain

[2] Univ Barcelona, Dept Quim Organ, E-08028 Barcelona, Spain

来源：

TETRAHEDRON | 2001年 / 57卷 / 47期

关键词：

thiouronium; ureas; coupling reagents; peptides; solid-phase;

D O I：

10.1016/S0040-4020(01)00985-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The thiouronium salts S-(1-oxido-2-pyridinyl)-1,1,3,3-tetramethylthiouronium hexafluorophosphate (HOTT) and tetrafluoroborate (TOTT), and S-(1-oxido-2-pyridinyl)-1,3-dimethyl-1,3-trimethylenethiouronium hexafluorophosphate (HODT) and tetrafluoroborate (TODT), prepared from 2-mercaptopyridine-1-oxide and 1, 1,3,3-tetramethylurea (TMU) or 1,3-dimethylpropyleneurea (DMPU), have been employed as reagents in solution and solid-phase peptide coupling chemistry. Furthermore, 2-mercaptopyridine-1-oxide has been employed as racemization-reducing additive combined with the new thiouronium salts and other frequently used peptide coupling reagents such as DCC or TBTU. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：9607 / 9613

页数：7

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