The triple helix: 50 years later, the outcome

被引：272

作者：

Duca, Maria ^{[4
]}

Vekhoff, Pierre ^{[1
,2
,3
]}

Oussedik, Kahina ^{[1
,2
,3
]}

Halby, Ludovic ^{[1
,2
]}

Arimondo, Paola B. ^{[1
,2
]}

机构：

[1] Museum Natl Hist Nat, CNRS, UMR 5153, USM0503, F-75231 Paris 05, France

[2] INSERM, UR565, F-75231 Paris 05, France

[3] Univ Paris 06, F-75005 Paris, France

[4] Univ Nice Sophia Antipolis, CNRS, UMR6001, LCMBA, F-06108 Nice 2, France

来源：

NUCLEIC ACIDS RESEARCH | 2008年 / 36卷 / 16期

关键词：

D O I：

10.1093/nar/gkn493

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Triplex-forming oligonucleotides constitute an interesting DNA sequence-specific tool that can be used to target cleaving or cross-linking agents, transcription factors or nucleases to a chosen site on the DNA. They are not only used as biotechnological tools but also to induce modifications on DNA with the aim to control gene expression, such as by site-directed mutagenesis or DNA recombination. Here, we report the state of art of the triplex-based anti-gene strategy 50 years after the discovery of such a structure, and we show the importance of the actual applications and the main challenges that we still have ahead of us.

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收藏

页码：5123 / 5138

页数：16

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