Geniposide from Gardenia jasminoides attenuates neuronal cell death in oxygen and glucose deprivation-exposed rat hippocampal slice culture

被引：46

作者：

Lee, P

Lee, J

Choi, SY

Lee, SE

Lee, S ^{[1
]}

Son, D

机构：

[1] Chung Ang Univ, Coll Ind Sci, Dept Appl Plant Sci, Anseong 456756, South Korea

[2] Natl Inst Agr Sci & Technol, Dept Agr Biol, Suwon 441100, South Korea

[3] Johns Hopkins Univ, Sch Med, Dept Anesthesiol & Crit Care Med, Baltimore, MD 21205 USA

[4] Korea Food Res Inst, Songnam 463746, South Korea

[5] Pulmuone Co Ltd, Inst Food & Culture, R&D Ctr Funct Foods, Seoul 120600, South Korea

[6] KT&G Cent Res Inst, Taejon 305805, South Korea

来源：

BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2006年 / 29卷 / 01期

关键词：

geniposide; Gardenia jusminoides; OGD; hippocampal slice culture;

D O I：

10.1248/bpb.29.174

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Geniposide from Gardenia jasminoides protected neuronal cells from damage in oxygen and glucose deprivation-exposed hippocampal slice culture. Geniposide showed a greater protective effect on the granule cell layer than on the pyramidal cell layer including CA 1 and CA 3. On the basis of the experimental results, geniposide may be a therapeutic agent for ischemia in patients.

引用

页码：174 / 176

页数：3

共 10 条

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[2] Lactate and glucose as energy substrates during, and after, oxygen deprivation in rat hippocampal acute and cultured slices [J].