Geniposide, an anti-angiogenic compound from the fruits of Gardenia jasminoides

被引：94

作者：

Koo, H

Lee, SY

Shin, KH

Kim, BC

Lirn, CJ

Park, EH ^{[1
]}

机构：

[1] Sookmyung Womens Univ, Coll Pharm, Seoul 140742, South Korea

[2] Seoul Natl Univ, Coll Pharm, Seoul, South Korea

[3] Seoul Natl Univ, Inst Nat Prod Res, Seoul, South Korea

[4] Kangwon Natl Univ, Div Life Sci, Chunchon, South Korea

来源：

PLANTA MEDICA | 2004年 / 70卷 / 05期

关键词：

D O I：

10.1055/s-2004-818978

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The EtOH extract of gardenia (Gardenia jasminoides Ellis) fruits was previously found to possess potent anti-angiogenic activity in the chick embryo chorioallantoic membrane (CAM) assay. Bioassay-guided fractionation and purification of the EtOH extract yielded an active anti-angiogenic compound, which was determined to be an iridoid glucoside, geniposide, by spectral analyses. Geniposide showed anti-angiogenic activity in a dose-dependent manner. It also exhibited an inhibitory effect in the range of 25 - 100 muM on the growth of the transformed NlH3T3 cell line.

引用

页码：467 / 469

页数：3

共 12 条

[1] Iridoid glucosides from Randia spinosa (Rubiaceae) [J].