Sequential mono-N-arylation of piperazine nitrogens.: Part 1:: A simplified method and its application to the preparation of a key N,N′-biaryl piperazine antifungal intermediate

被引:29
作者
Hepperle, M [1 ]
Eckert, J [1 ]
Gala, D [1 ]
机构
[1] Schering Plough Res Inst, Kenilworth, NJ 07033 USA
关键词
D O I
10.1016/S0040-4039(99)01103-X
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A simple sequential N-arylation of piperazine without the use of a protecting group, catalyst, specialized equipment or a large excess of piperazine, and its application towards the preparation of the key differentially N,N'-biarylated piperazine antifungal intermediate N-(4-hydroxyphenyl)-N'-(4-aminophenyl)piperazine, 6, is described. (C) 1999 Elsevier Science Ltd. All rights reserved.
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页码:5655 / 5659
页数:5
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