Sequential mono-N-arylation of piperazine nitrogens.: Part 1:: A simplified method and its application to the preparation of a key N,N′-biaryl piperazine antifungal intermediate

被引：29

作者：

Hepperle, M ^{[1
]}

Eckert, J ^{[1
]}

Gala, D ^{[1
]}

机构：

[1] Schering Plough Res Inst, Kenilworth, NJ 07033 USA

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 31期

关键词：

D O I：

10.1016/S0040-4039(99)01103-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple sequential N-arylation of piperazine without the use of a protecting group, catalyst, specialized equipment or a large excess of piperazine, and its application towards the preparation of the key differentially N,N'-biarylated piperazine antifungal intermediate N-(4-hydroxyphenyl)-N'-(4-aminophenyl)piperazine, 6, is described. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：5655 / 5659

页数：5

共 28 条

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