Hedgehog Signaling in Development and Cancer

被引：896

作者：

Jiang, Jin ^{[1
,2
]}

Hui, Chi-chung ^{[3
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Dev Biol, Dallas, TX 75390 USA

[2] Univ Texas SW Med Ctr Dallas, Dept Pharmacol, Dallas, TX 75390 USA

[3] Univ Toronto, Dept Mol Genet, Toronto, ON M5G 1L7, Canada

来源：

DEVELOPMENTAL CELL | 2008年 / 15卷 / 06期

关键词：

D O I：

10.1016/j.devcel.2008.11.010

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The Hedgehog (Hh) family of secreted proteins governs a wide variety of processes during embryonic development and adult tissue homeostasis. Here we review the current understanding of the molecular and cellular basis of Hh morphogen gradient formation and signal transduction, and the multifaceted roles of Hh signaling in development and tumorigenesis. We discuss how the Hh pathway has diverged during evolution and how it integrates with other signaling pathways to control cell growth and patterning.

引用

页码：801 / 812

页数：12

共 143 条

[61] The G12 family of heterotrimeric G proteins and Rho GTPase mediate Sonic hedgehog signalling [J].

Kasai, K ;

Takahashi, M ;

Osumi, N ;

Sinnarajah, S ;

Takeo, T ;

Ikeda, H ;

Kehrl, JH ;

Itoh, G ;

Arnheiter, H .

GENES TO CELLS, 2004, 9 (01) :49-58

[62] Roadkill attenuates Hedgehog responses through degradation of Cubitus interruptus [J].

Kent, D ;

Bush, EW ;

Hooper, JE .

DEVELOPMENT, 2006, 133 (10) :2001-2010

[63] Adenoviral vector-mediated transfer of the Indian hedgehog gene modulates lymphomyelopoiesis in vivo [J].

Kobune, Masayoshi ;

Kato, Junii ;

Kawano, Yutaka ;

Sasaki, Katsunori ;

Uchida, Hiroaki ;

Takada, Kohichi ;

Takahashi, Sho ;

Takimoto, Rishu ;

Niitsu, Yoshiro .

STEM CELLS, 2008, 26 (02) :534-542

[64] β-arrestin-mediated localization of smoothened to the primary cilium [J].

Kovacs, Jeffrey J. ;

Whalen, Erin J. ;

Liu, Renshui ;

Xiao, Kunhong ;

Kim, Jihee ;

Chen, Minyong ;

Wang, Jiangbo ;

Chen, Wei ;

Lefkowitz, Robert J. .

SCIENCE, 2008, 320 (5884) :1777-1781

[65] Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo [J].

Lai, K ;

Kaspar, BK ;

Gage, FH ;

Schaffer, DV .

NATURE NEUROSCIENCE, 2003, 6 (01) :21-27

[66] FUNCTION OF PROTEIN KINASE-A IN HEDGEHOG SIGNAL-TRANSDUCTION AND DROSOPHILA IMAGINAL DISC DEVELOPMENT [J].

LI, W ;

OHLMEYER, JT ;

LANE, ME ;

KALDERON, D .

CELL, 1995, 80 (04) :553-562

[67] Cholesterol modification restricts the spread of Shh gradient in the limb bud [J].

Li, YN ;

Zhang, HM ;

Litingtung, Y ;

Chiang, C .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (17) :6548-6553

[68] Functions of heparan sulfate proteoglycans in cell signaling during development [J].

Lin, XH .

DEVELOPMENT, 2004, 131 (24) :6009-6021

[69] Stroma-initiated hedgehog signaling takes center stage in B-cell lymphoma [J].

Lindemann, Ralph K. .

CANCER RESEARCH, 2008, 68 (04) :961-964

[70] Establishment and characterization of immortalized Gli-null mouse embryonic fibroblast cell lines [J].

Lipinski, Robert J. ;

Bijlsma, Maarten F. ;

Gipp, Jerry J. ;

Podhaizer, David J. ;

Bushman, Wade .

BMC CELL BIOLOGY, 2008, 9 (1)

← 2 3 4 5 6 7 8 9 10 11 →