ENDOSOMAL TRAFFICKING OF AMPA-TYPE GLUTAMATE RECEPTORS

被引：37

作者：

Hirling, H. ^{[1
]}

机构：

[1] Ecole Polytech Fed Lausanne, Fac Sci Vie, Brain Mind Inst, CH-1015 Lausanne, Switzerland

来源：

NEUROSCIENCE | 2009年 / 158卷 / 01期

基金：

瑞士国家科学基金会;

关键词：

internalization; receptor sorting; recycling; synaptic plasticity; post-synaptic; LONG-TERM POTENTIATION; TUBULOVESICULAR RECYCLING ENDOSOMES; MEDIATED SYNAPTIC-TRANSMISSION; AMYOTROPHIC-LATERAL-SCLEROSIS; CULTURED HIPPOCAMPAL-NEURONS; DENDRITIC SPINES; SILENT SYNAPSES; SUBUNIT GLUR2; MOLECULAR DETERMINANTS; POSTSYNAPTIC MEMBRANE;

D O I：

10.1016/j.neuroscience.2008.02.057

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Many different forms of synaptic plasticity have been shown to ultimately modulate the number of AMPA-type glutamate receptors at the synapse. This trafficking involves lateral movements between synaptic and extrasynaptic sites at the neuron surface, as well as vesicular transport between the plasma membrane and intracellular compartments. Several new studies have shed light on the location and regulation of AMPA-type receptor (AMPAR) endocytosis, their intracellular sorting to divergent pathways at the level of endosomes, and the mechanism and sites of receptor recycling. This review summarizes this recent data on the trafficking along the endocytic pathway, and follows the path of internalized AMPAR from endocytosis up to sites of recycling. (C) 2009 IBRO. Published by Elsevier Ltd. All rights reserved.

引用

页码：36 / 44

页数：9

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