Persistent epigenetic differences associated with prenatal exposure to famine in humans

被引：1927

作者：

Heijmans, Bastiaan T. ^{[1
]}

Tobi, Elmar W. ^{[1
]}

Stein, Aryeh D. ^{[4
]}

Putter, Hein ^{[2
]}

Blauw, Gerard J. ^{[3
]}

Susser, Ezra S. ^{[5
,6
]}

Slagboom, P. Eline ^{[1
]}

Lumey, L. H. ^{[5
]}

机构：

[1] Leiden Univ, Med Ctr, Dept Mol Epidemiol, Leiden, Netherlands

[2] Leiden Univ, Dept Med Stat, Med Ctr, NL-2300 RA Leiden, Netherlands

[3] Leiden Univ, Med Ctr, Dept Gerontol & Geriatr, NL-2300 RA Leiden, Netherlands

[4] Emory Univ, Hubert Dept Global Hlth, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA

[5] Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY 10032 USA

[6] New York State Psychiat Inst & Hosp, New York, NY 10032 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2008年 / 105卷 / 44期

基金：

美国国家卫生研究院;

关键词：

developmental origins; DNA methylation; insulin-like growth factor II; nutrition; periconception;

D O I：

10.1073/pnas.0806560105

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Extensive epidemiologic studies have suggested that adult disease risk is associated with adverse environmental conditions early in development. Although the mechanisms behind these relationships are unclear, an involvement of epigenetic dysregulation has been hypothesized. Here we show that individuals who were prenatally exposed to famine during the Dutch Hunger Winter in 1944-45 had, 6 decades later, less DNA methylation of the imprinted IGF2 gene compared with their unexposed, same-sex siblings. The association was specific for periconceptional exposure, reinforcing that very early mammalian development is a crucial period for establishing and maintaining epigenetic marks. These data are the first to contribute empirical support for the hypothesis that early-life environmental conditions can cause epigenetic changes in humans that persist throughout life.

引用

页码：17046 / 17049

页数：4

共 31 条

[1] The mammalian epigenome [J].

Bernstein, Bradley E. ;

Meissner, Alexander ;

Lander, Eric S. .

CELL, 2007, 128 (04) :669-681

[2] Intra-individual change over time in DNA methylation with familial clustering [J].

Bjornsson, Hans T. ;

Sigurdsson, Martin I. ;

Fallin, M. Daniele ;

Irizarry, Rafael A. ;

Aspelund, Thor ;

Cui, Hengmi ;

Yu, Wenqiang ;

Rongione, Michael A. ;

Ekstrom, Tomas J. ;

Harris, Tamara B. ;

Launer, Lenore J. ;

Eiriksdottir, Gudny ;

Leppert, Mark F. ;

Sapienza, Carmen ;

Gudnason, Vilmundur ;

Feinberg, Andrew P. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2008, 299 (24) :2877-2883

[3] Epigenetic modification of the renin-angiotensin system in the fetal programming of hypertension [J].

Bogdarina, Irina ;

Welham, Simon ;

King, Peter J. ;

Burns, Shamus P. ;

Clark, Adrian J. L. .

CIRCULATION RESEARCH, 2007, 100 (04) :520-526

[4] Dietary protein restriction of pregnant rats in the F0 generation induces altered methylation of hepatic gene promoters in the adult male offspring in the F1 and F2 generations [J].

Burdge, Graham C. ;

Slater-Jefferies, Jo ;

Torrens, Christopher ;

Phillips, Emma S. ;

Hanson, Mark A. ;

Lillycrop, Karen A. .

BRITISH JOURNAL OF NUTRITION, 2007, 97 (03) :435-439

[5]

Burger GCE, 1948, MALNUTRITION STARV 1

[6] Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls [J].

Burton, Paul R. ;

Clayton, David G. ;

Cardon, Lon R. ;

Craddock, Nick ;

Deloukas, Panos ;

Duncanson, Audrey ;

Kwiatkowski, Dominic P. ;

McCarthy, Mark I. ;

Ouwehand, Willem H. ;

Samani, Nilesh J. ;

Todd, John A. ;

Donnelly, Peter ;

Barrett, Jeffrey C. ;

Davison, Dan ;

Easton, Doug ;

Evans, David ;

Leung, Hin-Tak ;

Marchini, Jonathan L. ;

Morris, Andrew P. ;

Spencer, Chris C. A. ;

Tobin, Martin D. ;

Attwood, Antony P. ;

Boorman, James P. ;

Cant, Barbara ;

Everson, Ursula ;

Hussey, Judith M. ;

Jolley, Jennifer D. ;

Knight, Alexandra S. ;

Koch, Kerstin ;

Meech, Elizabeth ;

Nutland, Sarah ;

Prowse, Christopher V. ;

Stevens, Helen E. ;

Taylor, Niall C. ;

Walters, Graham R. ;

Walker, Neil M. ;

Watkins, Nicholas A. ;

Winzer, Thilo ;

Jones, Richard W. ;

McArdle, Wendy L. ;

Ring, Susan M. ;

Strachan, David P. ;

Pembrey, Marcus ;

Breen, Gerome ;

St Clair, David ;

Caesar, Sian ;

Gordon-Smith, Katherine ;

Jones, Lisa ;

Fraser, Christine ;

Green, Elain K. .

NATURE, 2007, 447 (7145) :661-678

[7] Genomic profiling of CpG methylation and allelic specificity using quantitative high-throughput mass spectrometry: critical evaluation and improvements [J].

Coolen, Marcel W. ;

Statham, Aaron L. ;

Gardiner-Garden, Margaret ;

Clark, Susan J. .

NUCLEIC ACIDS RESEARCH, 2007, 35 (18)

[8] Loss of IGF2 imprinting:: A potential marker of colorectal cancer risk [J].

Cui, HM ;

Cruz-Correa, M ;

Giardiello, FM ;

Hutcheon, DF ;

Kafonek, DR ;

Brandenburg, S ;

Wu, YQ ;

He, XB ;

Powe, NR ;

Feinberg, AP .

SCIENCE, 2003, 299 (5613) :1753-1755

[9] Could epigenetics play a role in the developmental origins of health and disease? [J].

Cutfield, Wayne S. ;

Hofman, Paul L. ;

Mitchell, Murray ;

Morison, Ian M. .

PEDIATRIC RESEARCH, 2007, 61 (05) :68R-75R

[10] Association of in vitro fertilization with Beckwith-Wiedemann syndrome and epigenetic alterations of LIT1 and H19 [J].

DeBaun, MR ;

Niemitz, EL ;

Feinberg, AP .

AMERICAN JOURNAL OF HUMAN GENETICS, 2003, 72 (01) :156-160

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