Identification of a novel protease inhibitor gene that is highly expressed in the prostate

被引：18

作者：

Lundwall, A ^{[1
]}

Clauss, A ^{[1
]}

机构：

[1] Lund Univ, Univ Hosp MAS, Dept Lab Med, S-20502 Malmo, Sweden

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2002年 / 290卷 / 01期

关键词：

semen; seminal plasma; protease inhibitor; WAP domain; prostate;

D O I：

10.1006/bbrc.2001.6224

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A novel gene was identified 52 kb upstream of the gene encoding the protease inhibitor elafin (PI3) on human chromosome 20q12-13.1. The transcript of the new gene, denoted huWAP2, was characterized by rapid amplification of cDNA ends and DNA sequencing. The size is 774 bp and it gives rise to a polypeptide of 111 amino acid residues that is homologous to elafin and similar WAP-type protease inhibitors. By RT-PCR it was shown that the gene is highly expressed in prostate, skin, lung, and esophagus. (C) 2002 Elsevier Science.

引用

页码：452 / 456

页数：5

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