Circulating MicroRNAs in Elderly Type 2 Diabetic Patients

被引：35

作者：

Catanzaro, Giuseppina ^{[1
]}

Besharat, Zein Mersini ^{[1
]}

Chiacchiarini, Martina ^{[2
]}

Abballe, Luana ^{[1
]}

Sabato, Claudia ^{[2
]}

Vacca, Alessandra ^{[1
]}

Borgiani, Paola ^{[3
]}

Dotta, Francesco ^{[4
]}

Tesauro, Manfredi ^{[5
]}

Po, Agnese ^{[2
]}

Ferretti, Elisabetta ^{[1
]}

机构：

[1] Sapienza Univ Rome, Dept Expt Med, Rome, Italy

[2] Sapienza Univ Rome, Dept Mol Med, Rome, Italy

[3] Tor Vergata Univ, Dept Biomed & Prevent, Rome, Italy

[4] Fdn Umberto Mario ONLUS, Rome, Italy

[5] Tor Vergata Univ, Dept Syst Med, Hypertens & Nephrol Unit, Rome, Italy

来源：

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY | 2018年 / 2018卷

关键词：

TO-MESENCHYMAL TRANSITION; BIOMARKERS; PLASMA; IDENTIFICATION; NEPHROPATHY; MIR-378; MIR-126;

D O I：

10.1155/2018/6872635

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

The circulating microRNAs (miRNAs) associated with type 2 diabetes (T2D) in elderly patients are still being defined. To identify novel miRNA biomarker candidates for monitoring responses to sitagliptin in such patients, we prospectively studied 40 T2D patients (age > 65) with HbA1c levels of 7.5-9.0% on metformin. After collection of baseline blood samples (t(0)), the dipeptidyl peptidase-IV (DPP-IV) inhibitor (DPP-IVi) sitagliptin was added to the metformin regimen, and patients were followed for 15 months. Patients with HbA1c < 7.5% or HbA1c reduction > 0.5% after 3 and 15 months of therapy were classified as "responders" (group R, n = 34); all others were classified as "nonresponders" (group NR, n = 6). Circulating miRNA profiling was performed on plasma collected in each group before and after 15 months of therapy (t(0) and t(15)). Intra-and intergroup comparison of miRNA profiles pinpointed three miRNAs that correlated with responses to sitagliptin: miR-378, which is a candidate biomarker of resistance to this DPP-IVi, and miR-126-3p and miR-223, which are associated with positive responses to the drug. The translational implications are as immediate as evident, with the possibility to develop noninvasive diagnostic tools to predict drug response and development of chronic complications.

引用

页数：11

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