Enantioselective solid-phase synthesis of α-amino acid derivatives

被引：95

作者：

O'Donnell, MJ ^{[1
]}

Delgado, F ^{[1
]}

Pottorf, RS ^{[1
]}

机构：

[1] Indiana Univ Purdue Univ, Dept Chem, Indianapolis, IN 46202 USA

来源：

TETRAHEDRON | 1999年 / 55卷 / 20期

关键词：

amino acids and derivatives; enantiocontrol; phase transfer; solid-phase synthesis;

D O I：

10.1016/S0040-4020(99)00211-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Wang-resin bound derivatives of glycine Schiff base esters are alkylated in the presence of quaternary ammonium salts derived from cinchonidine or cinchonine using phosphazene bases to give either enantiomer of the product a-amino acid derivatives in 51-89% ee. (C) 1999 Elsevier Science Ltd. All rights reserved. Keywords: Amino acids and derivatives, Enantiocontrol, Phase transfer, Solid-phase synthesis.

引用

页码：6347 / 6362

页数：16

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