Metallobiosites and their synthetic analogues - a belief in synergism - 1997-1998 Tilden Lecture

被引:131
作者
Fenton, DE [1 ]
机构
[1] Univ Sheffield, Dept Chem, Sheffield S3 7HF, S Yorkshire, England
关键词
D O I
10.1039/a805645e
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Just as it is possible to use coordination compounds to try and gain insight into the nature of metallobiosites so it is also possible to use the knowledge acquired through crystallography concerning the structure of a metallobiosite to try to develop new chemistry. The aim of this lecture was to illustrate this philosophy by referring to the interplay that led to the confirmation of the dicopper site in haemocyanin and by speculating on the use of knowledge acquired concerning the dinuclear site in urease to facilitate simulation of the functioning of the site.
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页码:159 / 168
页数:10
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