Cutting Edge: Local Recall Responses by Memory T Cells Newly Recruited to Peripheral Nonlymphoid Tissues

被引:51
作者
Wakim, Linda M. [1 ]
Gebhardt, Thomas [1 ]
Heath, William R. [1 ]
Carbone, Francis R. [1 ]
机构
[1] Univ Melbourne, Dept Microbiol & Immunol, Melbourne, Vic 3010, Australia
关键词
D O I
10.4049/jimmunol.181.9.5837
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Infection results in the formation of a circulating effector memory T cell population able to enter peripheral tissues either in the steady state or in response to localized infection. As a consequence, recall is thought to result from a phased response first involving those T cells already at the site of infection followed by the infiltration of memory cells from the wider circulation. We have recently reported that tissue-resident T cells can undergo stimulation and proliferation in response to local infection. In this study, we examine the proliferation of memory T cells newly recruited from the circulation. Our results show that although recruitment of circulating memory cells is nonspecific in nature, there is preferential proliferation of specific T cells within infected tissues. Thus, expansion represents a means of local Ag-specific enrichment of T cells recruited from a circulating memory pool of mixed specificities. The Journal of Immunology, 2008, 181: 5837-5841.
引用
收藏
页码:5837 / 5841
页数:5
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