Endothelial activation: intracellular signaling pathways

被引：161

作者：

Pober, Jordan S. ^{[1
]}

机构：

[1] Yale Univ, Boyer Ctr Mol Med, Sch Med, 295 Congress Ave,Room 454, New Haven, CT 06510 USA

来源：

ARTHRITIS RESEARCH & THERAPY | 2002年 / 4卷 / Suppl 3期

关键词：

adhesion molecules; cytokines; inflammation; leukocytes; tumor necrosis factor;

D O I：

10.1186/ar576

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Tumor necrosis factor (TNF) is the prototypic proinflammatory cytokine and endothelial cells are the principal cellular targets of its actions. Here I review the responses of endothelial cells to TNF, with emphasis on the induction of endothelial leukocyte adhesion molecules. I focus on the biochemistry and cell biology of signal transduction in TNF-treated endothelial cells that lead to the expression of adhesion molecules.

引用

页码：S109 / S116

页数：8

共 80 条

[1] CELL-TYPE-SPECIFIC TRANSACTIVATION OF THE VCAM-1 PROMOTER THROUGH AN NF-KAPPA-B ENHANCER MOTIF [J].

AHMAD, M ;

MARUI, N ;

ALEXANDER, RW ;

MEDFORD, RM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (15) :8976-8983

[2] Role of activating protein-1 in the regulation of the vascular cell adhesion molecule-1 gene expression by tumor necrosis factor-α [J].

Ahmad, M ;

Theofanidis, P ;

Medford, RM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (08) :4616-4621

[3] Expression of tumor necrosis factor receptors in normal kidney and rejecting renal transplants [J].

Al-Lamki, RS ;

Wang, J ;

Skepper, JN ;

Thiru, S ;

Pober, JS ;

Bradley, JR .

LABORATORY INVESTIGATION, 2001, 81 (11) :1503-1515

[4] P- and E-selectin mediate recruitment of T-helper-1 but not T-helper-2 cells into inflamed tissues [J].

Austrup, F ;

Vestweber, D ;

Borges, E ;

Lohning, M ;

Brauer, R ;

Herz, U ;

Renz, H ;

Hallmann, R ;

Scheffold, A ;

Radbruch, A ;

Hamann, A .

NATURE, 1997, 385 (6611) :81-83

[5] The NF-kappa B and I kappa B proteins: New discoveries and insights [J].

Baldwin, AS .

ANNUAL REVIEW OF IMMUNOLOGY, 1996, 14 :649-683

[6] Signal transduction by tumor necrosis factor and its relatives [J].

Baud, V ;

Karin, M .

TRENDS IN CELL BIOLOGY, 2001, 11 (09) :372-377

[7] INTERLEUKIN-1 ACTS ON CULTURED HUMAN VASCULAR ENDOTHELIUM TO INCREASE THE ADHESION OF POLYMORPHONUCLEAR LEUKOCYTES, MONOCYTES, AND RELATED LEUKOCYTE CELL-LINES [J].

BEVILACQUA, MP ;

POBER, JS ;

WHEELER, ME ;

COTRAN, RS ;

GIMBRONE, MA .

JOURNAL OF CLINICAL INVESTIGATION, 1985, 76 (05) :2003-2011

[8]

BJORK J, 1985, J IMMUNOL, V134, P1115

[9]

BRADLEY JR, 1995, AM J PATHOL, V146, P27

[10]

BRADLEY JR, 1993, J IMMUNOL, V150, P5544

← 1 2 3 4 5 6 7 8 →