Endothelial activation: intracellular signaling pathways

被引：161

作者：

Pober, Jordan S. ^{[1
]}

机构：

[1] Yale Univ, Boyer Ctr Mol Med, Sch Med, 295 Congress Ave,Room 454, New Haven, CT 06510 USA

来源：

ARTHRITIS RESEARCH & THERAPY | 2002年 / 4卷 / Suppl 3期

关键词：

adhesion molecules; cytokines; inflammation; leukocytes; tumor necrosis factor;

D O I：

10.1186/ar576

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Tumor necrosis factor (TNF) is the prototypic proinflammatory cytokine and endothelial cells are the principal cellular targets of its actions. Here I review the responses of endothelial cells to TNF, with emphasis on the induction of endothelial leukocyte adhesion molecules. I focus on the biochemistry and cell biology of signal transduction in TNF-treated endothelial cells that lead to the expression of adhesion molecules.

引用

页码：S109 / S116

页数：8

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