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The challenges of gene expression microarrays for the study of human cancer

被引：72
作者：
Tinker, Anna V.
Boussioutas, Alex
Bowtell, David D. L.
机构：
[1] Peter MacCallum Canc Ctr, Ian Potter Ctr Canc Genom & Predict Med, Melbourne, Vic 3002, Australia
[2] Univ Melbourne, Dept Med, Royal Melbourne Hosp, Footscray, Vic 3011, Australia
[3] Univ Melbourne, Western Hosp, Footscray, Vic 3011, Australia
[4] Univ Melbourne, Dept Biochem, Parkville, Vic 3052, Australia
来源：
CANCER CELL | 2006年 / 9卷 / 05期
基金：
加拿大健康研究院;
关键词：
D O I：
10.1016/j.ccr.2006.05.001
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Large-scale genomic studies promise to advance our understanding of the biology of human cancers and to improve their diagnosis, prognostication, and treatment. The analysis and interpretation of genomics studies have faced challenges. The retrospective and observational design of many studies has rendered them susceptible to confounding and bias. Technological variations and advancer, have impacted on reproducibility. Statistical hurdles in relating a large number of variables to a small number of observations have added further constraints. This review considers the promise and challenge associated with the large-scale clinically oriented genomic analysis of human cancer and attempts to emphasize potential solutions.
引用
收藏
页码：333 / 339
页数：7
相关论文
共 74 条
  • [1] Microarrays and breast cancer clinical studies: forgetting what we have not yet learnt
    Ahmed, AA
    Brenton, JD
    [J]. BREAST CANCER RESEARCH, 2005, 7 (03) : 96 - 99
  • [2] Standardizing global gene expression analysis between laboratories and across platforms
    Bammler, T
    Beyer, RP
    Bhattacharya, S
    Boorman, GA
    Boyles, A
    Bradford, BU
    Bumgarner, RE
    Bushel, PR
    Chaturvedi, K
    Choi, D
    Cunningham, ML
    Dengs, S
    Dressman, HK
    Fannin, RD
    Farun, FM
    Freedman, JH
    Fry, RC
    Harper, A
    Humble, MC
    Hurban, P
    Kavanagh, TJ
    Kaufmann, WK
    Kerr, KF
    Jing, L
    Lapidus, JA
    Lasarev, MR
    Li, J
    Li, YJ
    Lobenhofer, EK
    Lu, X
    Malek, RL
    Milton, S
    Nagalla, SR
    O'Malley, JP
    Palmer, VS
    Pattee, P
    Paules, RS
    Perou, CM
    Phillips, K
    Qin, LX
    Qiu, Y
    Quigley, SD
    Rodland, M
    Rusyn, I
    Samson, LD
    Schwartz, DA
    Shi, Y
    Shin, JL
    Sieber, SO
    Slifer, S
    [J]. NATURE METHODS, 2005, 2 (05) : 351 - 356
  • [3] CONTROLLING THE FALSE DISCOVERY RATE - A PRACTICAL AND POWERFUL APPROACH TO MULTIPLE TESTING
    BENJAMINI, Y
    HOCHBERG, Y
    [J]. JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY, 1995, 57 (01) : 289 - 300
  • [4] Global identification of human transcribed sequences with genome tiling arrays
    Bertone, P
    Stolc, V
    Royce, TE
    Rozowsky, JS
    Urban, AE
    Zhu, XW
    Rinn, JL
    Tongprasit, W
    Samanta, M
    Weissman, S
    Gerstein, M
    Snyder, M
    [J]. SCIENCE, 2004, 306 (5705) : 2242 - 2246
  • [5] BILD AH, 2005, NATURE, V439, P343
  • [6] Calculation of the minimum number of replicate spots required for detection of significant gene expression fold change in microarray experiments
    Black, MA
    Doerge, RW
    [J]. BIOINFORMATICS, 2002, 18 (12) : 1609 - 1616
  • [7] Towards complete and accurate reporting of studies of diagnostic accuracy: The STARD initiative
    Bossuyt, PM
    Reitsma, JB
    Bruns, DE
    Gatsonis, CA
    Glasziou, PP
    Irwig, LM
    Lijmer, JG
    Moher, D
    Rennie, D
    de Vet, HCW
    [J]. ANNALS OF INTERNAL MEDICINE, 2003, 138 (01) : 40 - 44
  • [8] Boussioutas A, 2003, CANCER RES, V63, P2569
  • [9] Minimum information about a microarray experiment (MIAME) - toward standards for microarray data
    Brazma, A
    Hingamp, P
    Quackenbush, J
    Sherlock, G
    Spellman, P
    Stoeckert, C
    Aach, J
    Ansorge, W
    Ball, CA
    Causton, HC
    Gaasterland, T
    Glenisson, P
    Holstege, FCP
    Kim, IF
    Markowitz, V
    Matese, JC
    Parkinson, H
    Robinson, A
    Sarkans, U
    Schulze-Kremer, S
    Stewart, J
    Taylor, R
    Vilo, J
    Vingron, M
    [J]. NATURE GENETICS, 2001, 29 (04) : 365 - 371
  • [10] The transcriptional landscape of the mammalian genome
    Carninci, P
    Kasukawa, T
    Katayama, S
    Gough, J
    Frith, MC
    Maeda, N
    Oyama, R
    Ravasi, T
    Lenhard, B
    Wells, C
    Kodzius, R
    Shimokawa, K
    Bajic, VB
    Brenner, SE
    Batalov, S
    Forrest, ARR
    Zavolan, M
    Davis, MJ
    Wilming, LG
    Aidinis, V
    Allen, JE
    Ambesi-Impiombato, X
    Apweiler, R
    Aturaliya, RN
    Bailey, TL
    Bansal, M
    Baxter, L
    Beisel, KW
    Bersano, T
    Bono, H
    Chalk, AM
    Chiu, KP
    Choudhary, V
    Christoffels, A
    Clutterbuck, DR
    Crowe, ML
    Dalla, E
    Dalrymple, BP
    de Bono, B
    Della Gatta, G
    di Bernardo, D
    Down, T
    Engstrom, P
    Fagiolini, M
    Faulkner, G
    Fletcher, CF
    Fukushima, T
    Furuno, M
    Futaki, S
    Gariboldi, M
    [J]. SCIENCE, 2005, 309 (5740) : 1559 - 1563
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