Microarrays and breast cancer clinical studies: forgetting what we have not yet learnt

被引：26

作者：

Ahmed, AA ^{[1
]}

Brenton, JD ^{[1
]}

机构：

[1] Univ Cambridge, Hutchison MRC Res Ctr, Dept Oncol, Canc Genom Programme, Cambridge, England

来源：

BREAST CANCER RESEARCH | 2005年 / 7卷 / 03期

关键词：

D O I：

10.1186/bcr1017

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

This review takes a sceptical view of the impact of breast cancer studies that have used microarrays to identify predictors of clinical outcome. In addition to discussing general pitfalls of microarray experiments, we also critically review the key breast cancer studies to highlight methodological problems in cohort selection, statistical analysis, validation of results and reporting of raw data. We conclude that the optimum use of microarrays in clinical studies requires further optimisation and standardisation of methodology and reporting, together with improvements in clinical study design.

引用

页码：96 / 99

页数：4

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