Cefepime is efficacious against penicillin- and quinolone-resistant pneumococci in experimental meningitis

被引：17

作者：

Cottagnoud, P ^{[1
]}

Acosta, F

Cottagnoud, M

Täuber, MG

机构：

[1] Inselspital Bern, Dept Internal Med, CH-3010 Bern, Switzerland

[2] Zieglerspital Bern, Dept Internal Med, CH-3007 Bern, Switzerland

[3] Univ Bern, Inst Infect Dis, CH-3010 Bern, Switzerland

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 2002年 / 49卷 / 02期

关键词：

D O I：

10.1093/jac/49.2.327

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

In experimental rabbit meningitis, cefepime given at a dose of 100 mg/kg was associated with concentrations in the cerebrospinal fluid of between 5.3 and 10 mg/L and a bactericidal activity of -0.61 +/- 0.24 Deltalog(10) cfu/mL.h, similar to the standard regimen of ceftriaxone combined with vancomycin (-0.58 +/- 0.14 Deltalog(10) cfu/mL.h) in the treatment of meningitis due to a penicillin- and quinolone-resistant pneumococcal mutant strain (MIC 4 mg/L). Compared with the penicillin-resistant parental strain, the penicillin- and quinolone-resistant mutant was killed more slowly by cefepime and ceftriaxone in time-killing assays in vitro over 8 h.

引用

页码：327 / 330

页数：4

共 17 条

[1] A critical evaluation of vancomycin for treatment of bacterial meningitis [J].

Ahmed, A .

PEDIATRIC INFECTIOUS DISEASE JOURNAL, 1997, 16 (09) :895-903

[2] The challenge of penicillin-resistant Streptococcus pneumoniae meningitis: Current antibiotic therapy in the 1990s [J].

Bradley, JS ;

Scheld, WM .

CLINICAL INFECTIOUS DISEASES, 1997, 24 :S213-S221

[3] Decreased susceptibility of Streptococcus pneumoniae to fluoroquinolones in Canada [J].

Chen, DK ;

McGeer, A ;

de Azavedo, JC ;

Low, DE .

NEW ENGLAND JOURNAL OF MEDICINE, 1999, 341 (04) :233-239

[4] Synergy between trovafloxacin and ceftriaxone against penicillin-resistant pneumococci in the rabbit meningitis model and in vitro [J].

Cottagnoud, P ;

Acosta, F ;

Cottagnoud, M ;

Neftel, K ;

Täuber, MG .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (08) :2179-2181

[5] EFFECT OF PROBENECID ON CEREBROSPINAL-FLUID CONCENTRATIONS OF PENICILLIN AND CEPHALOSPORIN DERIVATIVES [J].

DACEY, RG ;

SANDE, MA .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1974, 6 (04) :437-441

[6] EVALUATION OF ANTIMICROBIAL REGIMENS FOR TREATMENT OF EXPERIMENTAL PENICILLIN-RESISTANT AND CEPHALOSPORIN-RESISTANT PNEUMOCOCCAL MENINGITIS [J].

FRIEDLAND, IR ;

PARIS, M ;

EHRETT, S ;

HICKEY, S ;

OLSEN, K ;

MCCRACKEN, GH .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1993, 37 (08) :1630-1636

[7] Evaluation of cefepime alone and in combination with vancomycin against penicillin-resistant pneumococci in the rabbit meningitis model and in vitro [J].

Gerber, CM ;

Cottagnoud, M ;

Neftel, K ;

Täuber, MG ;

Cottagnoud, P .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2000, 45 (01) :63-68

[8]

GRASSI GG, 1991, J ANTIMICROB CHEMOTH, V32, P213

[9] Management of infections due to antibiotic-resistant Streptococcus pneumoniae [J].

Kaplan, SL ;

Mason, EO .

CLINICAL MICROBIOLOGY REVIEWS, 1998, 11 (04) :628-+

[10] A STUDY OF THE GENETIC MATERIAL DETERMINING AN ENZYME ACTIVITY IN PNEUMOCOCCUS [J].

LACKS, S ;

HOTCHKISS, RD .

BIOCHIMICA ET BIOPHYSICA ACTA, 1960, 39 (03) :508-518

← 1 2 →