Synergy between trovafloxacin and ceftriaxone against penicillin-resistant pneumococci in the rabbit meningitis model and in vitro

被引：23

作者：

Cottagnoud, P ^{[1
]}

Acosta, F

Cottagnoud, M

Neftel, K

Täuber, MG

机构：

[1] Inselspital Bern, Dept Internal Med, CH-3010 Bern, Switzerland

[2] Zieglerspital, Dept Internal Med, Bern, Switzerland

[3] Univ Bern, Inst Med Microbiol, Bern, Switzerland

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2000年 / 44卷 / 08期

关键词：

D O I：

10.1128/AAC.44.8.2179-2181.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The bactericidal activities of monotherapy with trovafloxacin (-0.37 +/- 1.15 Delta log(10) CFU/ml.h), vancomycin (-0.32 +/- 0.12 Delta log(10) CFU/ml.h), and ceftriaxone (-0.36 +/- 0.19 Delta log(10) CFU/ml.h) for the treatment of experimental meningitis in rabbits due to a clinical penicillin-resistant pneumococcal strain (MIC, 4 mg/liter) were similar. The combination of ceftriaxone with trovafloxacin considerably improved the killing rates (-0.67 +/- 0.16 Delta log(10) CFU/ml.h) and was slightly superior to ceftriaxone with vancomycin (killing rate, -0.53 +/- 0.22 Delta log(10) CFU/ml.h), the regimen most commonly used in clinical practice. In vitro, synergy was demonstrated between ceftriaxone and trovafloxacin by the checkerboard method (fractional inhibitory concentration index, 0.5) and by time-killing assays over 8 h.

引用

页码：2179 / 2181

页数：3

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