Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia

被引：319

作者：

Grabher, C ^{[1
]}

von Boehmer, H

Look, AT

机构：

[1] Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Boston, MA 02115 USA

[3] Dana Farber Canc Inst, Dept Canc Immunol & AIDS, Boston, MA 02115 USA

来源：

NATURE REVIEWS CANCER | 2006年 / 6卷 / 05期

关键词：

D O I：

10.1038/nrc1880

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The chromosomal translocation t(7; 9) in human T-cell acute lymphoblastic leukaemia (T-ALL) results in deregulated expression of a truncated, activated form of Notch 1 (TAN1) under the control of the T-cell receptor-beta (TCRB) locus. Although TAN1 efficiently induces T-ALL in mouse models, t( 7; 9) is present in less than 1% of human T-ALL cases. The recent discovery of novel activating mutations in NOTCH1 in more than 50% of human T-ALL samples has made it clear that Notch 1 is far more important in human T-ALL pathogenesis than previously suspected.

引用

页码：347 / 359

页数：13

共 176 条

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