The role and structure of mitochondrial carriers

被引：129

作者：

Kunji, ERS ^{[1
]}

机构：

[1] MRC, Dunn Human Nutr Unit, Cambridge CB2 2XY, England

来源：

FEBS LETTERS | 2004年 / 564卷 / 03期

基金：

英国医学研究理事会;

关键词：

mitochondrial carrier; electron crystallography; X-ray crystallography; structure; membrane protein;

D O I：

10.1016/S0014-5793(04)00242-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Members of the mitochondrial carrier family transport compounds over the inner mitochondrial membrane to link the biochemical pathways in the cytosol with those in the mitochondrial matrix. X-ray crystallography has recently provided us with the first atomic model of the bovine ADP/ATP carrier, which is a member of this family. The structure explains the typical three-fold sequence repeats and signature motif of mitochondrial carriers. However, the carrier was crystallised as a monomer in detergent, which is inconsistent with the consensus that mitochondrial carriers exist as homo-dimers. The projection structure of the yeast ADP/ATP carrier by electron crystallography shows that carriers could form homo-dimers in the membrane. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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页码：239 / 244

页数：6

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