Synthesis and anti-inflammatory activity of acetylenic thiophenes

被引：56

作者：

Zeni, G ^{[1
]}

Nogueira, CW

Panatieri, RB

Silva, DO

Menezes, PH

Braga, AL

Silveira, CC

Stefani, HA

Rocha, JBT

机构：

[1] UFSM, Lab Bioquim Toxicol, Dept Quim, BR-97105900 Santa Maria, RS, Brazil

[2] UFPE, Dept Quim Fundamental, Recife, PE, Brazil

[3] USP, Fac Ciencias Farmaceut, Sao Paulo, SP, Brazil

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 45期

基金：

巴西圣保罗研究基金会;

关键词：

D O I：

10.1016/S0040-4039(01)01703-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of acetylenic thiophene derivatives have been synthesized via Pd-catalyzed coupling reaction of 2-(butyltelluro)thiophene with a variety of terminal alkynes. These compounds showed good anti-inflammatory activity in the carrageenin-induced paw edema assay on rats. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：7921 / 7923

页数：3

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