Weakly ligated palladium complexes PdCl2(RCN)2 in piperidine:: versatile catalysts for Sonogashira reaction of vinyl chlorides at room temperature

被引：89

作者：

Alami, M ^{[1
]}

Crousse, B ^{[1
]}

Ferri, F ^{[1
]}

机构：

[1] Fac Pharm, Lab Chim Therapeut Associe CNRS, UPRESA 8076, BIOCIS, F-92296 Chatenay Malabry, France

来源：

JOURNAL OF ORGANOMETALLIC CHEMISTRY | 2001年 / 624卷 / 1-2期

关键词：

palladium; copper; amino vinyl chlorides; amino enynes; terbinafine;

D O I：

10.1016/S0022-328X(00)00909-8

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Copper iodide and weakly ligated palladium complexes PdCl2(RCN)(2) (R = Ph, Me) catalyzed efficiently the coupling reaction of vinyl chlorides with 1-alkynes in the presence of piperidine to give the corresponding conjugated enynes in good to excellent yields. The reaction takes place rapidly and cleanly at room temperature. Application to the synthesis of terbinafine which exhibits strong antimycotic activity has been realized. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：114 / 123

页数：10

共 52 条

[1] A two-step synthesis of terbinafine [J].