Biochemical studies on natural products, part 5 -: Enantioselective synthesis of (S)- and (R)-mappicines and their analogues

被引:23
作者
Das, B [1 ]
Madhusudhan, P [1 ]
机构
[1] Indian Inst Chem Technol, Div Organ Chem 1, Hyderabad 500007, Andhra Pradesh, India
关键词
D O I
10.1016/S0040-4020(99)00397-X
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The naturally occurring alkaloids, camptothecin and mappicine ketone were converted to racemic mappicine acetate which was enantioselectively hydrolyzed to (S)- and (R)-mappicines in high optical purity using baker's yeast and a lipase, Amano PS. Treatment of the racemic acetate with baker's yeast afforded (S)-mappicine while with Amano PS yielded (R)-mappicine. 9-Methoxycamptothecin and 9-methoxymappicine ketone underwent similar conversion to (S)- and (R)-9-methxymappicines. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:7875 / 7880
页数:6
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