Insulin-related peptides and their conserved signal transduction pathway

被引：158

作者：

Claeys, I ^{[1
]}

Simonet, G ^{[1
]}

Poels, J ^{[1
]}

Van Loy, T ^{[1
]}

Vercammen, L ^{[1
]}

De Loof, A ^{[1
]}

Vanden Broeck, J ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Lab Dev Physiol & Mol Biol, Louvain, Belgium

来源：

PEPTIDES | 2002年 / 23卷 / 04期

关键词：

aging; Caenorhabditis elegans; cell size; Drosophila melanogaster; growth; hormone; invertebrate; metabolism; obesity; peptide; receptor; reproduction;

D O I：

10.1016/S0196-9781(01)00666-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The 'insulin superfamily' is an ancient category of small, structurally related proteins, such as insulin, insulin-like growth factors (IGF) and relaxin. Insulin-like signaling molecules have also been described in different invertebrates, including nematodes, mollusks, and insects. They initiate an evolutionary conserved signal transduction mechanism by binding to a heterotetrameric, membrane-spanning receptor tyrosine kinase. Recent physiological and genetic studies have revealed that, in different metazoans, the insulin signaling pathway plays a pivotal role in the regulation of a variety of interrelated, fundamental processes, such as metabolism, growth, reproduction and aging. (C) 2002 Elsevier Science Inc. All rights reserved.

引用

页码：807 / 816

页数：10

共 93 条

[1] The genome sequence of Drosophila melanogaster [J].

Adams, MD ;

Celniker, SE ;

Holt, RA ;

Evans, CA ;

Gocayne, JD ;

Amanatides, PG ;

Scherer, SE ;

Li, PW ;

Hoskins, RA ;

Galle, RF ;

George, RA ;

Lewis, SE ;

Richards, S ;

Ashburner, M ;

Henderson, SN ;

Sutton, GG ;

Wortman, JR ;

Yandell, MD ;

Zhang, Q ;

Chen, LX ;

Brandon, RC ;

Rogers, YHC ;

Blazej, RG ;

Champe, M ;

Pfeiffer, BD ;

Wan, KH ;

Doyle, C ;

Baxter, EG ;

Helt, G ;

Nelson, CR ;

Miklos, GLG ;

Abril, JF ;

Agbayani, A ;

An, HJ ;

Andrews-Pfannkoch, C ;

Baldwin, D ;

Ballew, RM ;

Basu, A ;

Baxendale, J ;

Bayraktaroglu, L ;

Beasley, EM ;

Beeson, KY ;

Benos, PV ;

Berman, BP ;

Bhandari, D ;

Bolshakov, S ;

Borkova, D ;

Botchan, MR ;

Bouck, J ;

Brokstein, P .

SCIENCE, 2000, 287 (5461) :2185-2195

[2] Mechanism of activation and function of protein kinase B [J].

Alessi, DR ;

Cohen, P .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 1998, 8 (01) :55-62

[3] A HYPOGLYCEMIC FACTOR FROM THE CORPUS CARDIACUM OF THE AMERICAN COCKROACH PERIPLANETA-AMERICANA [J].

BARRETT, BA ;

LOUGHTON, BG .

GENERAL AND COMPARATIVE ENDOCRINOLOGY, 1987, 66 (01) :79-84

[4] THE DROSOPHILA ROLLED LOCUS ENCODES A MAP KINASE REQUIRED IN THE SEVENLESS SIGNAL-TRANSDUCTION PATHWAY [J].

BIGGS, WH ;

ZAVITZ, KH ;

DICKSON, B ;

VANDERSTRATEN, A ;

BRUNNER, D ;

HAFEN, E ;

ZIPURSKY, SL .

EMBO JOURNAL, 1994, 13 (07) :1628-1635

[5] SIGNAL-TRANSDUCTION VIA THE MAP KINASES - PROCEED AT YOUR OWN RSK [J].

BLENIS, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (13) :5889-5892

[6] Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4 [J].

Böhni, R ;

Riesgo-Escovar, J ;

Oldham, S ;

Brogiolo, W ;

Stocker, H ;

Andruss, BF ;

Beckingham, K ;

Hafen, E .

CELL, 1999, 97 (07) :865-875

[7] MOBILIZATION OF FAT BODY GLYCOGEN BY AN EXTRACT OF CORPUS CARDIACUM [J].

BOWERS, WS ;

FRIEDMAN, S .

NATURE, 1963, 198 (488) :685-&

[8] Neuropeptides and their precursors in the fruitfly, Drosophila melanogaster [J].

Broeck, JV .

PEPTIDES, 2001, 22 (02) :241-254

[9] An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control [J].

Brogiolo, W ;

Stocker, H ;

Ikeya, T ;

Rintelen, F ;

Fernandez, R ;

Hafen, E .

CURRENT BIOLOGY, 2001, 11 (04) :213-221

[10] A HUMAN CDNA CODING FOR THE LEYDIG INSULIN-SILE PEPTIDE (LEY I-L) [J].

BURKHARDT, E ;

ADHAM, IM ;

HOBOHM, U ;

MURPHY, D ;

SANDER, C ;

ENGEL, W .

HUMAN GENETICS, 1994, 94 (01) :91-94

← 1 2 3 4 5 6 7 8 9 10 →