Insulin-related peptides and their conserved signal transduction pathway

被引：158

作者：

Claeys, I ^{[1
]}

Simonet, G ^{[1
]}

Poels, J ^{[1
]}

Van Loy, T ^{[1
]}

Vercammen, L ^{[1
]}

De Loof, A ^{[1
]}

Vanden Broeck, J ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Lab Dev Physiol & Mol Biol, Louvain, Belgium

来源：

PEPTIDES | 2002年 / 23卷 / 04期

关键词：

aging; Caenorhabditis elegans; cell size; Drosophila melanogaster; growth; hormone; invertebrate; metabolism; obesity; peptide; receptor; reproduction;

D O I：

10.1016/S0196-9781(01)00666-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The 'insulin superfamily' is an ancient category of small, structurally related proteins, such as insulin, insulin-like growth factors (IGF) and relaxin. Insulin-like signaling molecules have also been described in different invertebrates, including nematodes, mollusks, and insects. They initiate an evolutionary conserved signal transduction mechanism by binding to a heterotetrameric, membrane-spanning receptor tyrosine kinase. Recent physiological and genetic studies have revealed that, in different metazoans, the insulin signaling pathway plays a pivotal role in the regulation of a variety of interrelated, fundamental processes, such as metabolism, growth, reproduction and aging. (C) 2002 Elsevier Science Inc. All rights reserved.

引用

页码：807 / 816

页数：10

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