Arabidopsis glutathione-dependent formaldehyde dehydrogenase is an S-nitrosoglutathione reductase

被引：180

作者：

Sakamoto, A ^{[1
]}

Ueda, M ^{[1
]}

Morikawa, H ^{[1
]}

机构：

[1] Japan Sci & Technol Corp, CREST, Kawaguchi, Saitama 3320012, Japan

来源：

FEBS LETTERS | 2002年 / 515卷 / 1-3期

基金：

日本学术振兴会;

关键词：

glutathione-dependent formaldehyde; dehydrogenase; S-nitrosoglutathione reductase; nitrosative stress; nitric oxide signaling; Arabidopsis;

D O I：

10.1016/S0014-5793(02)02414-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

S-Nitrosoglutathione (GSNO), an adduct of nitric oxide (NO) with glutathione, is known as a biological NO reservoir. Heterologous expression in Escherichia coli of a cDNA encoding a glutathione-dependent formaldehyde dehydrogenase of Arabidopsis thaliana showed that the recombinant protein reduces GSNO. The identity of the cDNA was further confirmed by functional complementation of the hypersensitivity to GSNO of a yeast mutant with impaired GSNO metabolism. This is the first demonstration of a plant GSNO reductase, suggesting that plants possess the enzymatic pathway that modulates the bioactivity and toxicity of NO. (C) 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：20 / 24

页数：5

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