Baker's yeast mediated biohydrogenation of unsaturated compounds containing a methylene group: enantioselective preparation of 2-methyl alkanols from 2-substituted acrolein acetals

被引：18

作者：

Ferraboschi, P

Reza-Elahi, S

Verza, E

Santaniello, E ^{[1
]}

机构：

[1] Univ Milan, Dipartimento Sci Preclin LITA Vialba, I-20122 Milan, Italy

[2] Univ Milan, Dipartimento Chim & Biochim Med, I-20122 Milan, Italy

来源：

TETRAHEDRON-ASYMMETRY | 1999年 / 10卷 / 14期

关键词：

D O I：

10.1016/S0957-4166(99)00256-6

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The baker's yeast mediated biohydrogenation of unsaturated compounds containing a methylene group may constitute an enantioselective biocatalytic approach to the preparation of 2-methyl-1-alkanols, as exemplified by the reduction of the compounds 8a-d to 90-98% enantiomerically pure alcohols 2a-d. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：2639 / 2642

页数：4

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[11] TOTAL SYNTHESIS OF NATURAL ALPHA-TOCOPHEROL .1. PREPARATION OF BIFUNCTIONAL OPTICALLY-ACTIVE PRECURSORS FOR THE SYNTHESIS OF THE SIDE-CHAIN BY MEANS OF MICROBIOLOGICAL TRANSFORMATIONS [J].