Indecent exposure: When telomeres become uncapped

被引：125

作者：

Ferreira, MG ^{[1
]}

Miller, KM ^{[1
]}

Cooper, JP ^{[1
]}

机构：

[1] Canc Res UK, Telomere Biol Lab, London WC2A 3PX, England

来源：

MOLECULAR CELL | 2004年 / 13卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S1097-2765(03)00531-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The protective "cap" that assembles at chromosome ends recruits and controls an intricate network of biochemical activities, each one critical for telomere structure and the maintenance of genomic stability. Recent studies have uncovered the components of telomere caps and have started to define the pathways that lead from telomere dysfunction to chromosomal catastrophe.

引用

页码：7 / 18

页数：12

共 103 条

[1] Rap1p telomere association is not required for mitotic stability of a C3TA2 telomere in yeast [J].

Alexander, MK ;

Zakian, VA .

EMBO JOURNAL, 2003, 22 (07) :1688-1696

[2] Targeting assay to study the cis functions of human telomeric proteins:: Evidence for inhibition of telomerase by TRF1 and for activation of telomere degradation by TRF2 [J].

Ancelin, K ;

Brunori, M ;

Bauwens, S ;

Koering, CE ;

Brun, C ;

Ricoul, M ;

Pommier, JP ;

Sabatier, L ;

Gilson, E .

MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (10) :3474-3487

[3] Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice [J].

Artandi, SE ;

Chang, S ;

Lee, SL ;

Alson, S ;

Gottlieb, GJ ;

Chin, L ;

DePinho, RA .

NATURE, 2000, 406 (6796) :641-645

[4] DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes [J].

Bailey, SM ;

Meyne, J ;

Chen, DJ ;

Kurimasa, A ;

Li, GC ;

Lehnert, BE ;

Goodwin, EH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (26) :14899-14904

[5] Strand-specific postreplicative processing of mammalian telomeres [J].

Bailey, SM ;

Cornforth, MN ;

Kurimasa, A ;

Chen, DJ ;

Goodwin, EH .

SCIENCE, 2001, 293 (5539) :2462-2465

[6] Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice [J].

Barnes, DE ;

Stamp, G ;

Rosewell, I ;

Denzel, A ;

Lindahl, T .

CURRENT BIOLOGY, 1998, 8 (25) :1395-1398

[7] Protection of telomeres by the Ku protein in fission yeast [J].

Baumann, P ;

Cech, TR .

MOLECULAR BIOLOGY OF THE CELL, 2000, 11 (10) :3265-3275

[8] Human Pot1 (Protection of telomeres) protein: Cytolocalization, gene structure, and alternative splicing [J].

Baumann, P ;

Podell, E ;

Cech, TR .

MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (22) :8079-8087

[9] Homologous recombination in human telomerase-positive and ALT cells occurs with the same frequency [J].

Bechter, OE ;

Zou, Y ;

Shay, JW ;

Wright, WE .

EMBO REPORTS, 2003, 4 (12) :1138-1143

[10] Telomere maintenance in fission yeast requires an Est1 ortholog [J].

Beernink, HTH ;

Miller, K ;

Deshpande, A ;

Bucher, P ;

Cooper, JP .

CURRENT BIOLOGY, 2003, 13 (07) :575-580

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