Indecent exposure: When telomeres become uncapped

被引：125

作者：

Ferreira, MG ^{[1
]}

Miller, KM ^{[1
]}

Cooper, JP ^{[1
]}

机构：

[1] Canc Res UK, Telomere Biol Lab, London WC2A 3PX, England

来源：

MOLECULAR CELL | 2004年 / 13卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S1097-2765(03)00531-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The protective "cap" that assembles at chromosome ends recruits and controls an intricate network of biochemical activities, each one critical for telomere structure and the maintenance of genomic stability. Recent studies have uncovered the components of telomere caps and have started to define the pathways that lead from telomere dysfunction to chromosomal catastrophe.

引用

页码：7 / 18

页数：12

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