Efficient loading of sulfonamide safety-catch linkers by Fmoc amino acid fluorides

被引：32

作者：

Ingenito, R ^{[1
]}

Dreznjak, D ^{[1
]}

Guffler, S ^{[1
]}

Wenschuh, H ^{[1
]}

机构：

[1] Jerini AG, D-12489 Berlin, Germany

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 07期

关键词：

D O I：

10.1021/ol0256320

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Fmoc-protected amino acid fluorides were found to be excellent reagents for the acylation of sulfonamide safety-catch linkers (SCL) suitable for the subsequent preparation of peptide C-terminal thioesters. High loadings were obtained on different types of resins with low levels of epimerization.

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页码：1187 / 1188

页数：2

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