Synthesis of the bicyclic core of CP-225,917 and CP-263,114 by an intramolecular Diels-Alder reaction

被引：45

作者：

Nicolaou, KC

Harter, MW

Boulton, L

Jandeleit, B

机构：

[1] Scripps Res Inst, SKAGGS INST CHEM BIOL, LA JOLLA, CA 92037 USA

[2] UNIV CALIF SAN DIEGO, DEPT CHEM & BIOCHEM, LA JOLLA, CA 92093 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1997年 / 36卷 / 11期

关键词：

bicycles; Diels-Alder reactions; natural products; synthetic methods;

D O I：

10.1002/anie.199711941

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

[No abstract available]

引用

页码：1194 / 1196

页数：3

共 15 条

[1]

[Anonymous], 1991, Comprehensive Organic Synthesis

[2] Farnesyl transferase inhibitors: The successes and surprises of a new class of potential cancer chemotherapeutics [J].

Buss, JE ;

Marsters, JC .

CHEMISTRY & BIOLOGY, 1995, 2 (12) :787-791

[3]

Ciganek E., 1984, ORG REACT NY, V32, P1, DOI DOI 10.1002/0471264180.OR032.01

[4] PROTEIN ISOPRENYLATION AND METHYLATION AT CARBOXYL-TERMINAL CYSTEINE RESIDUES [J].

CLARKE, S .

ANNUAL REVIEW OF BIOCHEMISTRY, 1992, 61 :355-386

[5]

Dabrah TT, 1997, J ANTIBIOT, V50, P1

[6] CP-225,917 and CP-263,114: Novel ras farnesylation inhibitors from an unidentified fungus .2. Structure elucidation [J].

Dabrah, TT ;

Kaneko, T ;

Massefski, W ;

Whipple, EB .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (07) :1594-1598

[7] REGULATION OF THE MEVALONATE PATHWAY [J].

GOLDSTEIN, JL ;

BROWN, MS .

NATURE, 1990, 343 (6257) :425-430

[8] BRIDGED TO FUSED-RING INTERCHANGE - NEW METHODOLOGY FOR THE CONSTRUCTION OF FUSED CYCLOHEPTANES AND CYCLOOCTANES [J].

GWALTNEY, SL ;

SAKATA, ST ;

SHEA, KJ .

TETRAHEDRON LETTERS, 1995, 36 (40) :7177-7180

[9]

HELMCHEN G, 1995, METHODEN ORG CHEM E, V21, P2872

[10]

HERTENSTEIN U, 1980, CHEM BER-RECL, V113, P3783, DOI 10.1002/cber.19801131211

← 1 2 →