Different modes of action of naphthyridones in gram-positive and gram-negative bacteria

被引：17

作者：

Buurman, ET

Johnson, KD

Kelly, RK

MacCormack, K

机构：

[1] AstraZeneca R&D Boston, Dept Microbiol, Waltham, MA 02451 USA

[2] AstraZeneca R&D Boston, Dept Mol Sci, Waltham, MA 02451 USA

[3] AstraZeneca R&D Boston, Dept Infect Discovery, Waltham, MA 02451 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2006年 / 50卷 / 01期

关键词：

D O I：

10.1128/AAC.50.1.385-387.2006

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Naphthyridones that were recently described as a class of translation inhibitors in gram-positive bacteria mediate their mode of action via GyrA in Haemophilus influenzae and Escherichia coli. These are the first examples of compounds in which modes of action in different bacterial pathogens are mediated through widely different targets.

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页码：385 / 387

页数：3

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