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Hodgkin's disease: A tumor with disturbed immunological pathways

被引：125
作者：
Gruss, HJ
Pinto, A
Duyster, J
Poppema, S
Herrmann, F
机构：
[1] CTR RIFERIMENTO ONCOL,DIV MED ONCOL,I-33081 AVIANO,ITALY
[2] UNIV GRONINGEN,DEPT PATHOL,NL-9713 EZ GRONINGEN,NETHERLANDS
来源：
IMMUNOLOGY TODAY | 1997年 / 18卷 / 04期
关键词：
D O I：
10.1016/S0167-5699(97)84661-0
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Hodgkin's disease is a lymphoid neoplasia characterized by a low frequency of malignant Hodgkin and Reed-Sternberg (H-RS) cells in an abundant background of non-neoplastic cells. H-RS cells and their neighbors interact via a complex network of cellular activation/adhesion molecules and cytokines. Here, Hans-Jurgen Gruss and colleagues suggest that H-RS cells can be regarded as antigen-presenting cells able to interact with surrounding T cells, resulting in an intense, but ineffective, immune response.
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收藏
页码：156 / 163
页数：8
相关论文
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