Hodgkin's disease: A tumor with disturbed immunological pathways

被引：125

作者：

Gruss, HJ

Pinto, A

Duyster, J

Poppema, S

Herrmann, F

机构：

[1] CTR RIFERIMENTO ONCOL,DIV MED ONCOL,I-33081 AVIANO,ITALY

[2] UNIV GRONINGEN,DEPT PATHOL,NL-9713 EZ GRONINGEN,NETHERLANDS

来源：

IMMUNOLOGY TODAY | 1997年 / 18卷 / 04期

关键词：

D O I：

10.1016/S0167-5699(97)84661-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Hodgkin's disease is a lymphoid neoplasia characterized by a low frequency of malignant Hodgkin and Reed-Sternberg (H-RS) cells in an abundant background of non-neoplastic cells. H-RS cells and their neighbors interact via a complex network of cellular activation/adhesion molecules and cytokines. Here, Hans-Jurgen Gruss and colleagues suggest that H-RS cells can be regarded as antigen-presenting cells able to interact with surrounding T cells, resulting in an intense, but ineffective, immune response.

引用

页码：156 / 163

页数：8

共 74 条

[51] IDENTIFICATION OF TARGET ANTIGENS FOR THE HUMAN CYTOTOXIC T-CELL RESPONSE TO EPSTEIN-BARR-VIRUS (EBV) - IMPLICATIONS FOR THE IMMUNE CONTROL OF EBV-POSITIVE MALIGNANCIES [J].

MURRAY, RJ ;

KURILLA, MG ;

BROOKS, JM ;

THOMAS, WA ;

ROWE, M ;

KIEFF, E ;

RICKINSON, AB .

JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 176 (01) :157-168

[52] SERUM LEVELS OF SOLUBLE CD30 ARE ELEVATED IN THE MAJORITY OF UNTREATED PATIENTS WITH HODGKINS-DISEASE AND CORRELATE WITH CLINICAL-FEATURES AND PROGNOSIS [J].

NADALI, G ;

VINANTE, F ;

AMBROSETTI, A ;

TODESCHINI, G ;

VENERI, D ;

ZANOTTI, R ;

MENEGHINI, V ;

RICETTI, MM ;

BENEDETTI, F ;

VASSANELLI, A ;

PERONA, G ;

CHILOSI, M ;

MENESTRINA, F ;

FIACCHINI, M ;

STEIN, H ;

PIZZOLO, G .

JOURNAL OF CLINICAL ONCOLOGY, 1994, 12 (04) :793-797

[53] Human eosinophils express functional CD30 ligand and stimulate proliferation of a Hodgkin's disease cell line [J].

Pinto, A ;

Aldinucci, D ;

Gloghini, A ;

Zagonel, V ;

Degan, M ;

Improta, S ;

Juzbasic, S ;

Todesco, M ;

Perin, V ;

Gattei, V ;

Herrmann, F ;

Gruss, HJ ;

Carbone, A .

BLOOD, 1996, 88 (09) :3299-3305

[54] HIGH SERUM LEVEL OF THE SOLUBLE FORM OF CD30 MOLECULE IN THE EARLY PHASE OF HIV-1 INFECTION AS AN INDEPENDENT PREDICTOR OF PROGRESSION TO AIDS [J].

PIZZOLO, G ;

VINANTE, F ;

MOROSATO, L ;

NADALI, G ;

CHILOSI, M ;

GANDINI, G ;

SINICCO, A ;

RAITERI, R ;

SEMENZATO, G ;

STEIN, H ;

PERONA, G .

AIDS, 1994, 8 (06) :741-745

[55] CHROMOSOMAL-ABNORMALITIES IN PATIENTS WITH HODGKINS-DISEASE - EVIDENCE FOR FREQUENT INVOLVEMENT OF THE 14Q-CHROMOSOMAL REGION BUT INFREQUENT BCL-2-GENE REARRANGEMENT IN REED-STERNBERG CELLS [J].

POPPEMA, S ;

KALETA, J ;

HEPPERLE, B .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1992, 84 (23) :1789-1793

[56]

POPPEMA S, 1989, AM J PATHOL, V135, P351

[57]

POPPEMA S, 1992, SEMIN DIAGN PATHOL, V9, P257

[58]

POPPEMA S, 1994, AM J PATHOL, V145, P37

[59]

POPPEMA S, 1985, CANCER, V55, P683, DOI 10.1002/1097-0142(19850215)55:4<683::AID-CNCR2820550402>3.0.CO

[60]

2-O

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