Anti-invasive effects of green tea polyphenol EpiGalloCatechin-3-gallate (EGCG), a natural inhibitor of metallo and serine proteases

被引：91

作者：

Benelli, R

Venè, R

Bisacchi, D

Garbisa, S

Albini, A ^{[1
]}

机构：

[1] Ist Nazl Ric Canc, I-16132 Genoa, Italy

[2] Fac Med, Dipartimento Sci Biomed Sperimentali, I-35121 Padua, Italy

[3] Ctr Biotecnol Avanzate, I-16132 Genoa, Italy

来源：

BIOLOGICAL CHEMISTRY | 2002年 / 383卷 / 01期

关键词：

antioxidant response elements (ARE); flavonoids; metalloproteinase (MMP); tumor invasion; urokinase (uPa);

D O I：

10.1515/BC.2002.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several reports have attributed to green tea chemopreventive and therapeutic properties. Epidemiological studies have linked the regular use of green tea to a reduced incidence of breast and colon carcinomas. Tea contains several antioxidants, including polyphenols of the catechin (green tea) and theaflavin (black tea) groups. Green tea derivatives have been shown to act in vitro and in vivo as anti-inflammatory, anti-viral and anti-tumor drugs. Despite the extensive body of data only few studies have investigated the molecular mechanisms underlying these effects. In this brief review we focus on the inhibitory activity of catechins derived from green tea toward proteases involved in tumor invasion.

引用

页码：101 / 105

页数：5

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