The synthesis and structure-activity relationships of 3-amino-4-benzylquinolin-2-ones: discovery of novel KCNQ2 channel openers

被引：20

作者：

Hewawasam, P

Chen, N

Ding, M

Natale, JT

Boissard, CG

Yeola, S

Gribkoff, VK

Starrett, J

Dworetzky, SI

机构：

[1] Bristol Myers Squibb Co, Pharmaceut Res Inst, Dept Chem, Wallingford, CT 06492 USA

[2] Bristol Myers Squibb Co, Pharmaceut Res Inst, Dept Neurosci, Wallingford, CT 06492 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 07期

关键词：

D O I：

10.1016/j.bmcl.2004.01.073

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

3-Amino-4-benzylquinolin-2-ones have been identified as a novel class of KCNQ2 channel openers. Synthesis and SAR is described along with their electrophysiological evaluation as activators of the cloned mKCNQ2 channel expressed in Xenopus laevis oocytes. The preliminary SAR data suggest the importance of both the trifluoromethylsulfonamido group and electron-withdrawing substituents on the quinolone nucleus for expression of KCNQ2 channel opening properties. (C) 2004 Elsevier Ltd. All rights reserved.

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页码：1615 / 1618

页数：4

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