Recent developments in the biology and medicinal chemistry of potassium channel modulators: Update from a decade of progress

被引：150

作者：

Coghlan, MJ ^{[1
]}

Carroll, WA ^{[1
]}

Gopalakrishnan, M ^{[1
]}

机构：

[1] Abbott Labs, Dept 47C, Div Pharmaceut Prod, Neurol & Urol Dis Res, Abbott Pk, IL 60064 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2001年 / 44卷 / 11期

关键词：

D O I：

10.1021/jm000484+

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

页码：1627 / 1653

页数：27

共 257 条

[1] MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia [J].

Abbott, GW ;

Sesti, F ;

Splawski, I ;

Buck, ME ;

Lehmann, WH ;

Timothy, KW ;

Keating, MT ;

Goldstein, SAN .

CELL, 1999, 97 (02) :175-187

[2] Toward understanding the assembly and structure of KATP channels [J].

Aguilar-Bryan, L ;

Clement, JP ;

Gonzalez, G ;

Kunjilwar, K ;

Babenko, A ;

Bryan, J .

PHYSIOLOGICAL REVIEWS, 1998, 78 (01) :227-245

[3] The signature sequence of voltage-gated potassium channels projects into the external vestibule [J].

Aiyar, J ;

Rizzi, JP ;

Gutman, GA ;

Chandy, KG .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (49) :31013-31016

[4] Mapping the functional anatomy of BgK on Kv1.1, Kv1.2, and Kv1.3 -: Clues to design analogs with enhanced selectivity [J].

Alessandri-Haber, N ;

Lecoq, A ;

Gasparini, S ;

Grangier-Macmath, G ;

Jacquet, G ;

Harvey, AL ;

de Medeiros, C ;

Rowan, EG ;

Gola, M ;

Ménez, A ;

Crest, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (50) :35653-35661

[5] CLINICAL-PHARMACOLOGY OF POTASSIUM CHANNEL OPENERS [J].

ANDERSSON, KE .

PHARMACOLOGY & TOXICOLOGY, 1992, 70 (04) :244-254

[6] Correlating structure and function in ATP-sensitive K+ channels [J].

Ashcroft, FM ;

Gribble, FM .

TRENDS IN NEUROSCIENCES, 1998, 21 (07) :288-294

[7] The β-cell KATP channel [J].

Ashcroft, SJH .

JOURNAL OF MEMBRANE BIOLOGY, 2000, 176 (03) :187-206

[8] Identification of the high-affinity tolbutamide site on the SUR1 subunit of the KATP channel [J].

Ashfield, R ;

Gribble, FM ;

Ashcroft, SJH ;

Ashcroft, FM .

DIABETES, 1999, 48 (06) :1341-1347

[9] Binding of ATP-sensitive potassium channel (KATP) openers to cardiac membranes:: Correlation of binding affinities with cardioprotective and smooth muscle relaxing potencies [J].

Atwal, KS ;

Grover, GJ ;

Lodge, NJ ;

Normandin, DE ;

Traeger, SC ;

Sleph, PG ;

Cohen, RB ;

Bryson, CC ;

Dickinson, KEJ .

JOURNAL OF MEDICINAL CHEMISTRY, 1998, 41 (03) :271-275

[10]

Atwal KS, 1996, CURR MED CHEM, V3, P227

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