Binding of ATP-sensitive potassium channel (KATP) openers to cardiac membranes:: Correlation of binding affinities with cardioprotective and smooth muscle relaxing potencies

被引：21

作者：

Atwal, KS ^{[1
]}

Grover, GJ ^{[1
]}

Lodge, NJ ^{[1
]}

Normandin, DE ^{[1
]}

Traeger, SC ^{[1
]}

Sleph, PG ^{[1
]}

Cohen, RB ^{[1
]}

Bryson, CC ^{[1
]}

Dickinson, KEJ ^{[1
]}

机构：

[1] Bristol Myers Squibb Pharmaceut Res Inst, Princeton, NJ 08543 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1998年 / 41卷 / 03期

关键词：

D O I：

10.1021/jm970762d

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

页码：271 / 275

页数：5

共 18 条

[1] ADVANCES IN THE STRUCTURE-ACTIVITY-RELATIONSHIPS, MECHANISMS OF ACTION, AND THERAPEUTIC UTILITIES OF ATP-SENSITIVE POTASSIUM CHANNEL OPENERS [J].

ATWAL, KS .

DRUG DEVELOPMENT RESEARCH, 1994, 33 (03) :250-262

[2] CARDIOSELECTIVE ANTIISCHEMIC ATP-SENSITIVE POTASSIUM CHANNEL OPENERS .2. STRUCTURE-ACTIVITY STUDIES ON BENZOPYRANYLCYANOGUANIDINES - MODIFICATION OF THE BENZOPYRAN RING [J].

ATWAL, KS ;

GROVER, GJ ;

FERRARA, FN ;

AHMED, SZ ;

SLEPH, PG ;

DZWONCZYK, S ;

NORMANDIN, DE .

JOURNAL OF MEDICINAL CHEMISTRY, 1995, 38 (11) :1966-1973

[3] ARYL CYANOGUANIDINE POTASSIUM CHANNEL OPENERS [J].

ATWAL, KS ;

MORELAND, S ;

MCCULLOUGH, JR ;

OREILLY, BC ;

AHMED, SZ ;

NORMANDIN, DE .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1992, 2 (01) :83-86

[4]

BRAY KM, 1992, J BIOL CHEM, V267, P11689

[5]

CHENG Y, 1973, BIOCHEM PHARMACOL, V22, P3099

[6]

DICKINSON KEJ, 1993, FASEB J, V7, pA354

[7]

DICKINSON KEJ, 1997, MOL PHARMACOL, V52, P1473

[8]

GADWOOD RC, 1996, Patent No. 5525742

[9] The mitochondrial K-ATP channel as a receptor for potassium channel openers [J].

Garlid, KD ;

Paucek, P ;

YarovYarovoy, V ;

Sun, XC ;

Schindler, PA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (15) :8796-8799

[10] ATP-SENSITIVE K+ CHANNELS - PHARMACOLOGICAL PROPERTIES, REGULATION, AND THERAPEUTIC POTENTIAL [J].

GOPALAKRISHNAN, M ;

JANIS, RA ;

TRIGGLE, DJ .

DRUG DEVELOPMENT RESEARCH, 1993, 28 (02) :95-127

← 1 2 →