Endocrine autoimmunity in families with type 1 diabetes: frequent appearance of thyroid autoimmunity during late childhood and adolescence

被引:17
作者
Bonifacio, E. [1 ,2 ]
Mayr, A. [3 ]
Knopff, A. [3 ]
Ziegler, A. -G. [3 ,4 ]
机构
[1] Tech Univ Dresden, DFG Res Ctr, D-8027 Dresden, Germany
[2] Tech Univ Dresden, Cluster Excellence Regenerat Therapies Dresden, D-8027 Dresden, Germany
[3] Tech Univ Munich, Klinikum Rechts Isar, Forschergrp Diabet, D-8000 Munich, Germany
[4] Stadt Klinikum Munchen, Klinikum Schwabing, Dept Endocrinol, Munich, Germany
关键词
Islet autoantibodies; Thyroid autoimmunity; Type; 1; diabetes; DISEASE-ASSOCIATED ANTIBODIES; AUTOANTIBODIES; CHILDREN; RISK; MELLITUS; RELATIVES; MANIFESTATIONS; SUSCEPTIBILITY; DECARBOXYLASE; PROGRESSION;
D O I
10.1007/s00125-008-1206-6
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Thyroid autoimmunity clusters with other endocrine and non-endocrine forms of autoimmunity. The aim of this study was to determine the chronological appearance of thyroid autoantibodies in relation to other forms of autoimmunity in at-risk children. The BABYDIAB study follows children of parents with type 1 diabetes. Children born in Germany between 1989 and 2000 were recruited at birth and followed up at 9 months and at 2, 5, 8, 11, 14 and 17 years. Antibodies to thyroid peroxidase were measured in samples taken at the last study visit in 1,489 children and in all previous samples in children who tested positive. Islet antibodies and antibodies to 21-hydroxylase and transglutaminase were also measured in all children. Median follow-up was 8 years. The cumulative risk for developing antibodies to thyroid peroxidase was 20.3% (95% CI 12.3-28.3) by age 14 years. The risk was increased in girls (adjusted HR 2.0; 95% CI 1.2-3.4; p = 0.008), in children who had multiple first-degree family history of type 1 diabetes (adjusted HR 3.3; 95% CI 1.4-8.0; p = 0.006) and in children who also had antibodies to GAD (adjusted HR 3.0; 95% CI 1.5-5.9; p = 0.001). Thyroid peroxidase antibody appearance was most common from age 8 years and was often the last autoantibody to develop in children with other autoantibodies. Among children of patients with type 1 diabetes, the appearance of thyroid autoantibodies is frequent, is not synchronous to the appearance of other autoantibodies and is most common in late childhood and adolescence.
引用
收藏
页码:185 / 192
页数:8
相关论文
共 36 条
[1]   Natural history of type 1 diabetes [J].
Achenbach, P ;
Bonifacio, E ;
Koczwara, K ;
Ziegler, AG .
DIABETES, 2005, 54 :S25-S31
[2]   Autoantibody "subspecificity" in type 1 diabetes - Risk for organ-specific autoimmunity clusters in distinct groups [J].
Barker, JM ;
Yu, J ;
Yu, LP ;
Wang, J ;
Miao, DM ;
Bao, F ;
Hoffenberg, E ;
Nelson, JC ;
Gottlieb, PA ;
Rewers, M ;
Eisenbarth, G .
DIABETES CARE, 2005, 28 (04) :850-855
[3]   Prediction of autoantibody positivity and progression to type 1 diabetes: Diabetes Autoimmunity Study in the Young (DAISY) [J].
Barker, JM ;
Barriga, KJ ;
Yu, LP ;
Miao, DM ;
Erlich, HA ;
Norris, JM ;
Eisenbarth, GS ;
Rewers, M .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2004, 89 (08) :3896-3902
[4]  
BETTERLE C, 1984, DIABETOLOGIA, V26, P431
[5]   Autoimmune adrenal insufficiency and autoimmune polyendocrine syndromes: Autoantibodies, autoantigens, and their applicability in diagnosis and disease prediction [J].
Betterle, C ;
Dal Pra, C ;
Mantero, F ;
Zanchetta, R .
ENDOCRINE REVIEWS, 2002, 23 (03) :327-364
[6]   THYROID AUTOANTIBODIES IN BLACK AND IN WHITE-CHILDREN AND ADOLESCENTS WITH TYPE-1 DIABETES-MELLITUS AND THEIR 1ST DEGREE RELATIVES [J].
BUREK, CL ;
ROSE, NR ;
GUIRE, KE ;
HOFFMAN, WH .
AUTOIMMUNITY, 1990, 7 (2-3) :157-167
[7]   Autoantibodies to thyroid peroxidase in patients with type 1 diabetes in Taiwan [J].
Chang, CC ;
Huang, CN ;
Chuang, LM .
EUROPEAN JOURNAL OF ENDOCRINOLOGY, 1998, 139 (01) :44-48
[8]   ANTIBODIES TO ISLET 37K ANTIGEN, BUT NOT TO GLUTAMATE-DECARBOXYLASE, DISCRIMINATE RAPID PROGRESSION TO IDDM IN ENDOCRINE AUTOIMMUNITY [J].
CHRISTIE, MR ;
GENOVESE, S ;
CASSIDY, D ;
BOSI, E ;
BROWN, TJ ;
LAI, M ;
BONIFACIO, E ;
BOTTAZZO, GF .
DIABETES, 1994, 43 (10) :1254-1259
[9]   PURIFICATION OF THE HUMAN THYROID PEROXIDASE AND ITS IDENTIFICATION AS THE MICROSOMAL ANTIGEN INVOLVED IN AUTOIMMUNE THYROID-DISEASES [J].
CZARNOCKA, B ;
RUF, J ;
FERRAND, M ;
CARAYON, P ;
LISSITZKY, S .
FEBS LETTERS, 1985, 190 (01) :147-152
[10]   Extrapancreatic autoimmune manifestations in type 1 diabetes patients and their first-degree relatives - A multicenter study [J].
Hanukoglu, A ;
Mizrachi, A ;
Dalal, I ;
Admoni, O ;
Rakover, Y ;
Bistritzer, Z ;
Levine, A ;
Somekh, E ;
Lehmann, D ;
Tuval, M ;
Boaz, M ;
Golander, A .
DIABETES CARE, 2003, 26 (04) :1235-1240