Effect of adrenaline on glucose kinetics during exercise in adrenalectomised humans

被引:43
作者
Howlett, K
Galbo, H
Lorentsen, J
Bergeron, R
Zimmerman-Belsing, T
Bülow, J
Feldt-Rasmussen, U
Kjær, M [1 ]
机构
[1] Bispebjerg Hosp, Dept Rheumatol, Sports Med Res Unit, DK-2400 Copenhagen, Denmark
[2] Bispebjerg Hosp, Copenhagen Muscle Res Ctr, DK-2400 Copenhagen, Denmark
[3] Rigshosp, Dept Endocrinol, DK-2200 Copenhagen, Denmark
[4] Univ Copenhagen, Panum Inst, Dept Med Physiol, DK-2200 Copenhagen, Denmark
[5] Yale Univ, Sch Med, Dept Endocrinol, New Haven, CT USA
[6] Deakin Univ, Sch Hlth Sci, Burwood 3125, Australia
来源
JOURNAL OF PHYSIOLOGY-LONDON | 1999年 / 519卷 / 03期
关键词
D O I
10.1111/j.1469-7793.1999.0911n.x
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
1. The role of adrenaline in regulating hepatic glucose production and muscle glucose uptake during exercise nas examined in six adrenaline-deficient, bilaterally adrenalectomised humans. Six sex- and age-matched healthy individuals served as controls (CON). 2. Adrenalectomised subjects cycled for 45 min at 68 +/- 1% maximum pulmonary O-2 uptake ((V) over dot(O2,max)) followed by 15 min at 84 +/- 2% (V) over dot(O2,max) without (-ADR) or with (+ADR) adrenaline infusion, which elevated plasma adrenaline levels (45 min, 4.49 +/- 0.69 nmol l(-1); 60 min, 12.41 +/- 1.80 nmol l(-1); means +/- S.E.M.). Glucose kinetics were measured using [3-H-3]glucose. 3. Euglycaemia was maintained during exercise in CON and -ADR, whilst in +ADR plasma glucose was elevated. The exercise-induced increase in hepatic glucose production was similar in +ADR and -ADR; however, adrenaline infusion augmented the rise in hepatic glucose production early in exercise. Glucose uptake increased during exercise in +ADR and -ADR, but was lower and metabolic clearance rate was reduced in +ADR. 4. During exercise noradrenaline and glucagon concentrations increased, and insulin and cortisol concentrations decreased, but plasma levels were similar between trials. Adrenaline infusion suppressed growth hormone and elevated plasma free fatty acids, glycerol and lactate. Alanine and beta-hydroxybutyrate levels were similar between trials. 5. The results demonstrate that glucose homeostasis was maintained during exercise in adrenalectomised subjects. Adrenaline does not appear to play a major role in matching hepatic glucose production to the increase in glucose clearance. In contrast, adrenaline infusion results in a mismatch by simultaneously enhancing hepatic glucose production and inhibiting glucose clearance.
引用
收藏
页码:911 / 921
页数:11
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