Cancer - Many vessels, faulty gene

被引：34

作者：

Kaelin, WG ^{[1
]}

机构：

[1] Howard Hughes Med Inst, Boston, MA 02115 USA

[2] Dana Farber Canc Inst, Dept Adult Oncol, Boston, MA 02115 USA

[3] Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA

[4] Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA

来源：

NATURE | 1999年 / 399卷 / 6733期

关键词：

D O I：

10.1038/20309

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The von Hippel-Lindau (VHL) cancer syndrome is caused by mutations in theVHLgene, and is characterized by development of blood-vessel tumours. Production of blood vessels is normally stimulated when cells are short of oxygen. But when oxygen is plentiful, the factors that stimulate production of vessels are destroyed. It now turns out that the VHL protein is responsible for this destruction. So, when it is mutated, the result is too many vessels and tumour formation.

引用

页码：203 / 204

页数：2

共 14 条

[11] Reconstitution of G1 cyclin ubiquitination with complexes containing SCFGrr1 and Rbx1 [J].