Dog MHC alleles containing the human RA shared epitope confer susceptibility to canine rheumatoid arthritis

被引:72
作者
Ollier, WER [1 ]
Kennedy, LJ
Thomson, W
Barnes, AN
Bell, SC
Bennett, D
Angles, JM
Innes, JF
Carter, SD
机构
[1] Univ Liverpool, Fac Vet Med, Mammalian Immunogenet Res Grp, Liverpool L69 3BX, Merseyside, England
[2] Univ Glasgow, Fac Vet Sci, Glasgow G12 8QQ, Lanark, Scotland
[3] Univ Coll, Fac Vet Med, Dublin, Ireland
基金
英国惠康基金;
关键词
DLA-DRB1; dog; MHC; rheumatoid arthritis; shared epitope;
D O I
10.1007/s002510100372
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
To determine whether canine rheumatoid arthritis (CRA) is associated with dog MHC (DLA-DRB1) alleles which contain the QRRAA/RKRAA conserved third hypervariable region (3HVR) sequence, DNA samples were extracted from 61 dogs with clinically diagnosed small-joint polyarthritis and from 425 controls. Breed-matched controls were available for 41 cases. DLA-DRB1 genotypes were identified using molecular typing methods. Phenotype frequencies were compared between cases and controls and odds ratios with 95% confidence intervals calculated. Several DLA-DRB1 alleles were associated with increased risk for CRA: DLA-DRB1*002, DRB1*009, and DRB1*018. This was also observed for the presence of any shared epitope (SE)bearing allele. The associations with DLA-DRB1*002 and the SE were maintained when only breed-matched cases and controls were compared. This study suggests that a conserved amino acid motif in the 3HVR present in some DRB1 alleles of both dogs and humans is associated with rheumatoid arthritis in both species.
引用
收藏
页码:669 / 673
页数:5
相关论文
共 19 条
[1]   CONTRIBUTION OF T-CELL RECEPTOR-CONTACTING AND PEPTIDE-BINDING RESIDUES OF THE CLASS-II MOLECULE HLA-DR4 DW10 TO SEROLOGIC AND ANTIGEN-SPECIFIC T-CELL RECOGNITION [J].
BARBER, LD ;
BAL, V ;
LAMB, JR ;
OHEHIR, RE ;
YENDLE, J ;
HANCOCK, RJT ;
LECHLER, RI .
HUMAN IMMUNOLOGY, 1991, 32 (02) :110-118
[2]  
BARI ASM, 1989, BRIT J RHEUMATOL, V28, P480
[3]   CANINE-DISTEMPER VIRAL-ANTIGENS AND ANTIBODIES IN DOGS WITH RHEUMATOID-ARTHRITIS [J].
BELL, SC ;
CARTER, SD ;
BENNETT, D .
RESEARCH IN VETERINARY SCIENCE, 1991, 50 (01) :64-68
[5]  
BENNETT D, 1987, J COMP PATHOL, V97, P54550
[6]   IMMUNE-COMPLEXES AND RHEUMATOID FACTORS IN CANINE ARTHRITIDES [J].
CARTER, SD ;
BELL, SC ;
BARI, ASM ;
BENNETT, D .
ANNALS OF THE RHEUMATIC DISEASES, 1989, 48 (12) :986-991
[7]  
GOLDINGS EA, 1993, ARTHRITIS ALLIED CON, P525
[8]   THE SHARED EPITOPE HYPOTHESIS - AN APPROACH TO UNDERSTANDING THE MOLECULAR-GENETICS OF SUSCEPTIBILITY TO RHEUMATOID-ARTHRITIS [J].
GREGERSEN, PK ;
SILVER, J ;
WINCHESTER, RJ .
ARTHRITIS AND RHEUMATISM, 1987, 30 (11) :1205-1213
[9]   Immunocytochemical demonstration of lymphocyte subsets and MHC class II antigen expression in synovial membranes from dogs with rheumatoid arthritis and degenerative joint disease [J].
Hewicker-Trautwein, M ;
Carter, SD ;
Bennett, D ;
Kelly, DF .
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 1999, 67 (04) :341-357
[10]   DLA-DRB1 polymorphisms in dogs defined by sequence-specific oligonucleotide probes (SSOP) [J].
Kennedy, LJ ;
Carter, SD ;
Barnes, A ;
Bell, S ;
Bennett, D ;
Ollier, B ;
Thomson, W .
TISSUE ANTIGENS, 1999, 53 (02) :184-189