Gold-catalyzed intramolecular reaction of indoles with alkynes: Facile formation of eight-membered rings and an unexpected allenylation

被引:359
作者
Ferrer, C
Echavarren, AM
机构
[1] Inst Chem Res Catalonia ICIQ, Tarragona 43007, Spain
[2] Univ Autonoma Madrid, Dept Quim Organ, E-28049 Madrid, Spain
关键词
alkynes; allenes; cyclization; gold; indoles;
D O I
10.1002/anie.200503484
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
(Chemical Equation Presented) Going for gold: Cationic gold(I) complexes favor formation of six- and seven-membered rings by 6-endo-dig, 6-exo-dig, and 7-exo-dig cyclizations of alkynyl indoles, whereas indoloazocines are favored with AuCl3 as catalyst (see scheme). Allenes are also formed by a fragmentation process. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
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页码:1105 / 1109
页数:5
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