Synthesis and functionalization of Indoles through palladium-catalyzed reactions

Over the past decades palladium catalysis has achieved an important place in the arsenal of organic chemists involved in the construction and functionalization of indole derivatives. Palladium-catalyzed reactions have become a very powerful tool in this area. Several areas of the palladium-catalyzed indole chemistry have been the object of an increasing number of studies, which include the development of new synthetic strategies, the optimization of reaction conditions, the utilization of solid-phase synthesis and microwave-assisted conditions, the construction of indole libraries, and the application to the synthesis of bioactive derivatives.